Personal profile
About
My research focuses on the development of learning and memory. A variety of behavioral procedures, with a special emphasis on classical eyeblink conditioning, enable us to study both the neural and behavioral processes that support different forms of associative learning across different stages of infant development. We are especially interested in characterizing the parallels between learning in human infants and in young rats pups that can be explained by similarities in central nervous system development. These studies focus on relating developmental changes in the cerebellum, hippocampus, amygdala, and prefrontal cortex to changes in associative learning skills during infancy. Recently, we have been exploring, in rats, the detrimental effects of elevated plasma corticosterone levels on learning during critical periods of postnatal development, looking into potential interventions to reduce the impairment, and using immunohistochemical methods and confocal fluorescence microscopy to examine changes brain development. The ultimate goal of this type of research is to enhance our understanding of developmental learning disorders and how memory processing changes over the course of the developmental life span.
Related documents
Research Interests
- Behavioral Neuroscience
- Learning and Memory
- Cerebellum
Disciplines
- Life Sciences
- Neuroscience and Neurobiology
- Social and Behavioral Sciences
- Psychology
- Biological Psychology
- Cognitive Psychology
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Influence of Postnatal Glucocorticoids on Hippocampal-Dependent Learning Varies with Elevation Patterns and Administration Methods
Claflin, D. I., Schmidt, K. D., Vallandingham, Z. D., Kraszpulski, M. & Hennessy, M. B., Sep 2017, In: Neurobiology of Learning and Memory. 143, p. 77-87 11 p.Research output: Contribution to journal › Article › peer-review
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Short-Term, High-Dose Administration of Corticosterone by Injection Facilitates Trace Eyeblink Conditioning in Young Male Rats
Wentworth-Eidsaune, C. L., Hennessy, M. B. & Claflin, D. I., Feb 1 2016, In: Behavioural Brain Research. 298Research output: Contribution to journal › Article › peer-review
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Infant stress exposure produces persistent enhancement of fear learning across development
Quinn, J. J., Skipper, R. A. & Claflin, D. I., Jul 2014, In: Developmental Psychobiology. 56, 5, p. 1008-1016 9 p.Research output: Contribution to journal › Article › peer-review
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Modest Elevation of Corticosterone in Preweaning Rats Impairs Subsequent Trace Eyeblink Conditioning During the Juvenile Period
Claflin, D. I., Greenfield, L. R. & Hennessy, M. B., Jan 1 2014, In: Behavioural Brain Research. 258Research output: Contribution to journal › Article › peer-review
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Responses of Guinea Pigs to Brain Stimulation during Isolation: Examining the Transition from ''Protest'' to Depressive-Like Behavior
Claflin, D. I., Schiml, P. A., Kardegar, N., Caudill, J., Floyd, R., Deak, T., Panksepp, J. & Hennessy, M. B., Jun 1 2013, In: Neurology, Psychiatry and Brain Research. 19Research output: Contribution to journal › Article › peer-review