Research output per year
Research output per year
Personal profile
About
My research interests are in the areas of cerebrovascular diseases and diabetes, specifically in developing novel predictive and therapeutic avenues for ischemic stroke, hemorrhagic stroke, and vascular complications of diabetes. My ongoing research topics include:
- Extracellular microvesicles (MVs) and exosomes (EXs) in brain disorders and diabetic vascular complications.
- Endothelial progenitor cells (EPCs) in neurological dysfunction, vascular protection, and tissue repair.
- Exosomal communications between adipose tissue and brain/vessels.
- MVs and EXs in skin injury and wound healing.
EPC priming for functional enhancement with an angiotensin-converting enzyme (ACE2) or CXCR4 has been studied in my research. The effects of cardiovascular risk factors on the release and cargoes (proteins and microRNAs) of EPC-EXs are currently under investigation. The cross-talk mediated by MVs or EXs between endothelial cells and brain cells, as well as endothelium and keratinocytes are also currently being explored. More recently, the role of exosomes released from adipose tissue in modulating the function of vessels and the brain is being studied.
Related documents
Education/Academic qualification
Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine
2014 → …
Internal Medicine, Ph.D., Medical Science Center, Peking University
2010 → …
Clinical Medicine, M.D., Hengyang Medical College, Nanhua University
2005 → …
External positions
Associate Professor, Marshall University
Research Interests
- Cerebrovascular Diseases
- Diabetes
- Endothelial Progenitor Cells
Disciplines
- Life Sciences
- Pharmacology, Toxicology and Environmental Health
- Medicine and Health Sciences
- Chemicals and Drugs
- Amino Acids, Peptides, and Proteins
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Cardiovascular Diseases
- Disease Modeling
- Biological Phenomena, Cell Phenomena, and Immunity
- Chemical and Pharmacologic Phenomena
- Neurosciences
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EPC-EXs Improve Astrocyte Survival and Oxidative Stress Through Different Uptaking Pathways in Diabetic Hypoxia Condition
Halurkar, M. S., Wang, J., Chen, S. & Bihl, J. C., Dec 1 2022, In: Stem Cell Research & Therapy. 13Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Role of Exosomes in Mediating the Cross-Talk Between Adipose Tissue and the Brain
Yerrapragada, S. M. & Bihl, J. C., Jun 1 2022, In: NeuroMolecular Medicine. 24Research output: Contribution to journal › Article › peer-review
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Ultraviolet B Irradiation Alters the Level and miR Contents of Exosomes Released by Keratinocytes in Diabetic Condition
Wang, J., Pothana, K., Chen, S., Sawant, H., Travers, J. B., Bihl, J. & Chen, Y., Sep 1 2022, In: Photochemistry and Photobiology. 98, 5, p. 1122-1130 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
EPC-EXs Improve Neuronal Survival and Oxidative Stress Through Different Uptaking Pathways in Diabetic Hypoxia Condition
Halurkar, M. S., Wang, J., Chen, S. & Bihl, J. C., Oct 11 2021, In: Research Square.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation-Induced Systemic Immunosuppression
Liu, L., Awoyemi, A. A., Fahy, K. E., Thapa, P., Borchers, C. E., Wu, B. Y., McGlone, C. L., Schmeusser, B., Sattouf, Z., Rohan, C. A., Williams, A. R., Cates, E. E., Kinsely, C., Kelly, L. E., Bihl, J. C., Cool, D. R., Sahu, R. P., Wang, J., Chen, Y. & Rapp, C. M. & 3 others, , Apr 8 2021, In: The Journal of Clinical Investigation. 131, 10Research output: Contribution to journal › Article › peer-review
Open Access