Personal profile
About
My current research interests focus on:
1. Understanding and manipulating the Renin-Angiotensin System (RAS) relevant to hypertension and diabetes.
2. Use of MALDI- TOF-MS and SELDI-TOF-MS to develop and optimize miniaturized novel assays for quantitative evaluation of localized and circulating RAS.
3. Our recent work focused on the development of urinary Angiotensin Converting Enzyme (ACE2 ) and neprilysin (NEP) as biomarkers for early detection of Chronic Kidney Disease in diabetic patients.
Our laboratory uses radio telemetry, confocal microscopy, western blot and enzyme assay to investigate the effect of hyperglycemia on blood pressure, renal RAS and progression of CKD in murine model of diabetes and hypertension.
Previous research interests were focused on extraction, purification and characterization of insulin mimetic molecules from Plasmodium yoelii. These molecules are related to Glycosylphosphatiylinositos (GPIs) which could have a potential as new antidiabetic agents.
Research is funded by NHLBI, American Heart Association, WSU Boonshoft School of Medicine.
Related documents
Education/Academic qualification
School of Pharmacy, Pharm.D., Ohio Northern University
School of Pharmacy, MS, University of Bradford
School of Pharmacy, B. Pharm, University of Khartoum
Ph.D., University of Strathclyde
Research Interests
- Mechanisms of Disease
- Diabetes
- Chronic Kidney Disease
Disciplines
- Medicine and Health Sciences
- Pharmacy and Pharmaceutical Sciences
-
Insulin restores renal neprilysin (NEP) and attenuates the shedding of urinary NEP and KIM-1 in diabetic Akita mice
Gill, R. K., Salem, E. S. B., Grobe, N. & Elased, K. M., 2026, In: Frontiers in Pharmacology. 16, 1679651.Research output: Contribution to journal › Article › peer-review
Open Access -
Strategies for inducing and validating zinc deficiency and zinc repletion
Wenegieme, T. Y., Elased, D., McMichael, K. E., Rockwood, J., Hasrat, K., Ume, A. C., Marshall, A. G., Neikirk, K., Kirabo, A., Elased, K. M., Hinton, A. & Williams, C. R., Jun 2024, In: American Journal of Physiology - Heart and Circulatory Physiology. 326, 6, p. H1396-H1401Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension
Alawi, L. F., Dhakal, S., Emberesh, S. E., Sawant, H., Hosawi, A., Thanekar, U., Grobe, N. & Elased, K. M., Jan 29 2021, In: Frontiers in Pharmacology. 11, 602985.Research output: Contribution to journal › Article › peer-review
Open Access -
The IL-8-CXCR1/2 axis contributes to diabetic kidney disease
Loretelli, C., Rocchio, F., D'Addio, F., Ben Nasr, M., Castillo-Leon, E., Dellepiane, S., Vergani, A., Abdelsalam, A., Assi, E., Maestroni, A., Usuelli, V., Bassi, R., Pastore, I., Yang, J., El Essawy, B., Elased, K. M., Fadini, G. P., Ippolito, E., Seelam, A. J. & Pezzolesi, M. & 6 others, , Aug 2021, In: Metabolism: Clinical and Experimental. 121, 154804.Research output: Contribution to journal › Article › peer-review
-
Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice
Alawi, L. F., Emberesh, S. E., Owuor, B. A., Chodavarapu, H., Fadnavis, R., El-Amouri, S. S. & Elased, K. M., Feb 1 2020, In: Physiological Reports. 8, 3, e14364.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
- 8 Membership of network
-
American Society of Physiology (ASP) (External organization)
Elased, K. M. (Member)
Jan 1 2014 → …Activity: Membership › Membership of network
-
American Society of Nephrology (ASN) (External organization)
Elased, K. M. (Member)
Jan 1 2013 → …Activity: Membership › Membership of network
-
American College of Clinical Pharmacy (ACCP) (External organization)
Elased, K. M. (Member)
Jan 1 2011 → …Activity: Membership › Membership of network
-
Delegate of Boonshoft School of Medicine to the United States Pharmacopeia (USP) Conventions (External organization)
Elased, K. M. (Member)
Jan 1 2010 → …Activity: Membership › Membership of network
-
American Society for Pharmacology and Experimental Therapeutics (ASPET) (External organization)
Elased, K. M. (Member)
Jan 1 2005 → Jan 1 2009Activity: Membership › Membership of network