Search results

• 2024

  IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells

  Wong, V. A., Dinh, K. N., Chen, G. & Wrenshall, L. E., 2024, In: Frontiers in Immunology. 15, 1369818.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue

  Martinez, H. A., Koliesnik, I., Kaber, G., Reid, J. K., Nagy, N., Barlow, G., Falk, B. A., Medina, C. O., Hargil, A., Zihsler, S., Vlodavsky, I., Li, J. P., Pérez-Cruz, M., Tang, S. W., Meyer, E. H., Wrenshall, L. E., Lord, J. D., Garcia, K. C., Palmer, T. D. & Steinman, L. & 4 others, Nepom, G. T., Wight, T. N., Bollyky, P. L. & Kuipers, H. F., Dec 2024, In: Nature Communications. 15, 1, 1564.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  Expression of a functional IL-2 receptor in vascular smooth muscle cells

  Arumugam, P., Carroll, K. L., Berceli, S. A., Barnhill, S. & Wrenshall, L. E., Feb 1 2019, In: Journal of Immunology. 202, 3, p. 694-703 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Measuring proliferation of vascular smooth muscle cells using click chemistry

  Wong, V., Arumugam, P. & Wrenshall, L. E., Oct 1 2019, In: Journal of Visualized Experiments. 2019, 152, e59930.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Regulation of Vascular Smooth Muscle Cell Responses by IL-2/IL-2R Alpha

  Wong, V., Hui, D., Matsuura, J. H. & Wrenshall, L. E., May 1 2019.

  Research output: Contribution to conference › Presentation
• 2018

  Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2–CD36 functional interdependence

  Ganesan, R., Henkels, K. M., Wrenshall, L. E., Kanaho, Y., Paolo, G. D., Frohman, M. A., Gomez-Cambronero, J. & DiPaolo, G., May 1 2018, In: Journal of Leukocyte Biology. 103, 5, p. 867-883 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2016

  A Double-Blind, Double-Dummy, Flexible-Design Randomized Multicenter Trial: Early Safety of Single- Versus Divided-Dose Rabbit Anti-Thymocyte Globulin Induction in Renal Transplantation

  Stevens, R. B., Wrenshall, L. E., Miles, C. D., Farney, A. C., Jie, T., Sandoz, J. P., Rigley, T. H., Osama Gaber, A. & Gaber, O., Jun 1 2016, In: American Journal of Transplantation. 16, 6, p. 1858-1867 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2015

  A randomized 2×2 factorial trial, Part 1: Single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes

  Stevens, R. B., Foster, K. W., Miles, C. D., Lane, J. T., Kalil, A. C., Florescu, D. F., Sandoz, J. P., Rigley, T. H., Nielsen, K. J., Skorupa, J. Y., Kellogg, A. M., Malik, T. & Wrenshall, L. E., Jan 15 2015, In: Transplantation. 99, 1, p. 197-209 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• A randomized 2x2 factorial clinical trial of renal transplantation: Steroid-free maintenance immunosuppression with calcineurin inhibitor withdrawal after six months associates with improved renal function and reduced chronic histopathology

  Stevens, R. B., Foster, K. W., Miles, C. D., Kalil, A. C., Florescu, D. F., Sandoz, J. P., Rigley, T. H., Malik, T. & Wrenshall, L. E., Oct 14 2015, In: PLoS ONE. 10, 10, e0139247.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Dimeric IL-2 Induces Necrosis of Interleukin-2 Receptor Positive Cells

  Ganesan, R., Arumugam, P., Clabaugh, S. E., Kozak, J. A. & Wrenshall, L. E., May 2015, The Journal of Immunology. 1_Supplement ed. Vol. 194. (The Journal of Immunology).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  Open Access

• Dimeric IL-2 Induces Necrosis of Interleukin-2 Receptor Positive Cells

  Ganesan, R., Arumugam, P., Clabaugh, S. E., Kozak, J. A. & Wrenshall, L. E., May 1 2015

  Research output: Other contribution

• Heparan sulfate proteoglycan metabolism and the fate of grafted tissues

  Platt, J. L., Wrenshall, L. E., Johnson, G. B. & Cascalho, M., Jan 1 2015, In: Advances in Experimental Medicine and Biology. 865, p. 123-140 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2014

  Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues

  Wrenshall, L. E., Clabaugh, S. E., Cool, D. R., Arumugam, P., Grunwald, W. C., Smith, D. R., Liu, G. C. & Miller, J. D., Jul 14 2014, In: PLoS ONE. 9, 7, e102191.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2013

  Heparan Sulfate-Bound Dimeric IL-2: A Potential Mediator of Renal Ischemic Injury

  Dixon, L. A., Miller, J. D., Clabaugh, S. E., Liu, G. C., Stuever, M. F. & Wrenshall, L. E., Apr 1 2013, The FASEB Journal.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• 2012

  Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase

  Miller, J. D., Clabaugh, S. E., Smith, D. R., Stevens, R. B. & Wrenshall, L. E., Feb 2012, In: Immunology and Cell Biology. 90, 2, p. 159-167 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase

  Miller, J. D., Clabaugh, S. E., Smith, D. R., Stevens, R. B. & Wrenshall, L. E., Feb 1 2012, In: Immunology and Cell Biology. 90, 2, p. 159–167

  Research output: Contribution to journal › Article › peer-review

• Loss of Renal Allografts Secondary to Candida Vascular Complications in Two Recipients from the Same Donor

  Yannam, G. R., Wrenshall, L. E. & Stevens, R. B., Jan 1 2012, In: Case Reports in Transplantation. 2012

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Single-dose rATG induction at renal transplantation: Superior renal function and glucoregulation with less hypomagnesemia

  Stevens, R. B., Lane, J. T., Boerner, B. P., Miles, C. D., Rigley, T. H., Sandoz, J. P., Nielsen, K. J., Skorupa, J. Y., Skorupa, A. J., Kaplan, B. & Wrenshall, L. E., Jan 1 2012, In: Clinical Transplantation. 26, 1, p. 123-132 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Significantly Reduced Renal Allograft Histopathology after Single-Dose rATG Induction and Calcineurin-Inhibitor Withdrawal vs. Minimization: Final Report from a Prospective, Randomized Clinical Trial

  Stevens, R. B., Foster, K. W., Lane, J. T., Miles, C. D., Kalil, A. C., Sandoz, J. P., Rigley, T. H., Skorupa, J. Y., Kellogg, A. M. & Wrenshall, L. E., Apr 1 2011, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Sitagliptin therapy in kidney transplant recipients with new-onset diabetes after transplantation

  Lane, J. T., Odegaard, D. E., Haire, C. E., Collier, D. S., Wrenshall, L. E. & Stevens, R. B., Nov 27 2011, In: Transplantation. 92, 10, p. e56-e57

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• 2010

  Calcineurin-Inhibitor Withdrawal vs. Minimization after Kidney Transplantation Is Safe but Does Not Improve Renal Function; 5-Year Results of a Prospective, Randomized Trial

  Stevens, R. B., Skorupa, J. Y., Rigley, T. H., Sandoz, J. P., Kellogg, A. M., Miller, N. R., Nielsen, K. J., Miles, C. D. & Wrenshall, L. E., Apr 1 2010, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Interleukin-2 Is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase

  Clabaugh, S. E., Miller, J. D., Smith, D. R., Stevens, R. B. & Wrenshall, L. E., Apr 2010, American Journal of Transplantation. S4 ed. Vol. 10. p. 312 (American Journal of Transplantation).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Reduced Patient Mortality and Infectious Complications, and Superior Graft Function, in Renal Transplant Patients after Single-Dose RATG Induction; 5-Year Data from a Prospective, Randomized Trial

  Stevens, R. B., Kalil, A. C., Miles, C. D., Florescu, D. I., Lane, J. T., Skorupa, A. J., Rigley, T. H., Skorupa, J. Y., Sandoz, J. P., Nielsen, K. J., Kellogg, A. M., Miller, N. R. & Wrenshall, L. E., Apr 1 2010, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Single-Dose Rabbit Anti-Thymocyte Globulin (rATG) Induction Reduces Tubular Injury after Renal Transplantation, Resulting in Superior Renal Function, Serum Mg++ Retention, and Glucose Regulation

  Stevens, R. B., Lane, J. T., Boerner, B. P., Miles, C. D., Rigley, T. H., Sandoz, J. P., Nielsen, K. J., Skorupa, J. Y., Skorupa, A. J. & Wrenshall, L. E., Apr 1 2010, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• 2009

  Acute Transverse Myelitis and Paralysis in a Kidney–Pancreas Recipient

  Brian Stevens, R., Yannam, G. R., Skorupa, J. Y., Rigley, T. H., Penn, D. M. & Wrenshall, L. E., Jul 2009, In: Transplant International. 22, 7, p. 766-768 3 p.

  Research output: Contribution to journal › Article › peer-review

• Calcineurin-Inhibitor (CI) Discontinuation Following Early Steroid Withdrawal (ESW) in Renal Allograft Recipients without Increased Rejection or Graft Loss

  Stevens, R. B., Rigley, T. H., Nielsen, K. J., Skorupa, J. Y., Skorupa, A. J., Sandoz, J. P. & Wrenshall, L. E., May 1 2009, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Increased primary non-function in transplanted deceased-donor kidneys flushed with histidine-tryptophan-ketoglutarate solution

  Stevens, R. B., Skorupa, J. Y., Rigley, T. H., Yannam, G. R., Nielsen, K. J., Schriner, M. E., Skorupa, A. J., Murante, A., Holdaway, E. & Wrenshall, L. E., May 1 2009, In: American Journal of Transplantation. 9, 5, p. 1055-1062 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Single-Dose Induction with Rabbit Anti-Thymocyte Globulin (rATG; 6 mg/kg over 24 Hours) Is Safer and Improves Immediate and Long-Term Renal Allograft Function

  Stevens, R. B., Rigley, T. H., Nielsen, K. J., Skorupa, A. J., Sandoz, J. P., Kellogg, A. M. & Wrenshall, L. E., May 1 2009, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• 2008

  A Case-Matched, Retrospective, Single-Center Study Comparing Low-Dose Tacrolimus/Sirolimus and Tacrolimus/MMF after Renal Transplantation with Early Steroid Withdrawal after rATG Induction

  Stevens, R. B., Henning, M. E., Rigley, T. H., Nielsen, K. J., Miles, C. D., Rao, V., Groggel, G. C. & Wrenshall, L. E., May 1 2008, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Cytomegalovirus viremia in solid organ transplantation: Does the initial viral load correlate with risk factors and outcomes?

  Levitsky, J., Freifeld, A. G., Puumala, S., Bargenquast, K., Hardiman, P., Gebhart, C., Wrenshall, L., Langnas, A. & Kalil, A. C., Mar 2008, In: Clinical Transplantation. 22, 2, p. 222-228 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Hashimoto's encephalopathy after intensive lymphocyte depletion with rabbit anti-thymocyte globulin in a renal transplant patient

  Stevens, R. B., Wakefield, C. B., Alonso, D., Skorupa, J. Y., Rigley, T. H., Penn, D. M. & Wrenshall, L. E., Jan 1 2008, In: American Journal of Transplantation. 8, 1, p. 245-249 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Increased pancreatitis in allografts flushed with histidine-tryptophan- ketoglutarate solution: A cautionary tale

  Alonso, D., Dunn, T. B., Rigley, T., Skorupa, J. Y., Schriner, M. E., Wrenshall, L. E. & Stevens, R. B., Sep 2008, In: American Journal of Transplantation. 8, 9, p. 1942-1945 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Long Term Follow-Up after Early Steroid Withdrawal and Calcineurin-Inhibitor Minimization in Moderate to High Immunologic Risk Renal Transplant Recipients Including ABO Incompatible and Donor-Specific Antibody (DSA)

  Stevens, R. B., Wrenshall, L. E., Mercer, D. F., Henning, M. E., Rigley, T. H., Skorupa, J. Y., Nielsen, K. J., Skorupa, A. J., Freifeld, A. G., Miles, C. D., Rao, V. & Groggel, G. C., May 1 2008, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Perlecan: A major IL-2-binding proteoglycan in murine spleen

  Miller, J. D., Stevens, E. T., Smith, D. R., Wight, T. N. & Wrenshall, L. E., Feb 1 2008, In: Immunology and Cell Biology. 86, 2, p. 192-199 8 p.

  Research output: Contribution to journal › Article › peer-review

• Randomized trial of single-dose versus divided-dose rabbit anti-thymocyte globulin induction in renal transplantation: an interim report

  Stevens, R. B., Mercer, D. F., Grant, W. J., Freifeld, A. G., Lane, J. T., Groggel, G. C., Rigley, T. H., Nielsen, K. J., Henning, M. E., Skorupa, J. Y., Skorupa, A. J., Christensen, K. A., Sandoz, J. P., Kellogg, A. M., Langnas, A. N. & Wrenshall, L. E., May 27 2008, In: Transplantation. 85, 10, p. 1391-1399 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Single-Dose Induction with Rabbit Anti-Thymocyte Globulin (rATG) Safely Improves Renal Allograft Function and Reduces Chronic Allograft Nephropathy

  Stevens, R. B., Mercer, D. F., Rigley, T. H., Nielsen, K. J., Henning, M. E., Skorupa, A. J., Sandoz, J. P., Kellogg, A. M., Rao, V., Miles, C. D., Groggel, G. C. & Wrenshall, L. E., May 1 2008, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Successful Calcineurin-Inhibitor (CI) Discontinuation Following Early Steroid Withdrawal (ESW) in Renal Allograft Recipients; Reduced Chronic Allograft Nephropathy (CAN) and Improved Renal Function without Increased Rejection or Graft Loss

  Stevens, R. B., Wrenshall, L. E., Mercer, D. F., Rigley, T. H., Nielsen, K. J., Henning, M. E., Skorupa, J. Y., Skorupa, A. J., Sandoz, J. P., Kellogg, A. M., Miles, C. D., Rao, V. & Groggel, G. C., May 1 2008, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2007

  ABO Incompatible Renal Transplantation Using Steroid-Free Immunosuppression

  Wrenshall, L. E., Stevens, R. B., Grant, W. J. & Mercer, D. F., May 1 2007, In: American Journal of Transplantation. 7

  Research output: Contribution to journal › Article › peer-review

• Improved Renal Graft Function Following Single-Dose rATG (6 mg/Kg/24h) Induction

  Stevens, R. B., Mercer, D. F., Grant, W. J., Henning, M. E., Nielsen, K. J., Rigley, T. H. & Wrenshall, L. E., Jan 1 2007, In: American Journal of Transplantation. 7

  Research output: Contribution to journal › Article › peer-review

• Influence of interleukin-2 deficiency on the generation of autoimmune B cells

  Wrenshall, L. E., Smith, D. R., Stevens, E. T. & Miller, J. D., Sep 1 2007, In: Journal of Autoimmunity. 29, 2-3, p. 125-133 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Low Dose Tacrolimus in Combination with Sirolimus in Renal Transplantation Is Not Associated with Graft Loss or Dysfunction; a Retrospective, Case-Matched Single-Center Experience

  Stevens, R. B., Henning, M. E., Rigley, T. H., Nielsen, K. J. & Wrenshall, L. E., Jan 1 2007, In: American Journal of Transplantation. 7

  Research output: Contribution to journal › Article › peer-review

• Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: Implications for the role of interleukin-2 in thymic function

  Wrenshall, L. E., Stevens, E. T., Smith, D. R. & Miller, J. D., Feb 1 2007, In: Cellular Immunology. 245, 2, p. 80-90 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Successful Calcineurin-Inhibitor Discontinuation Following Early Steroid Withdrawal in Renal Allograft Recipients Is Associated with Reduced Chronic Allograft Nephropathy, Improved Renal Function without Increased Risk of Rejection

  Stevens, R. B., Grant, W. J., Mercer, D. F., Rigley, T. H., Nielson, K., Henny, M. & Wrenshall, L. E., May 1 2007, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Successful Early Steroid Withdrawal and Calcineurin-Inhibitor Minimization in Moderate to High Immunological Risk Renal Transplant Recipients Including ABO and Cross Match Positive Recipients

  Stevens, R. B., Wrenshall, L. E., Grant, W. J., Mercer, D. F., Botha, J. F., Sudan, D. L. & Langnas, A. N., May 1 2007, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• 2006

  Interleukin-2 and the Regulation of Autoimmune B Cells

  Wrenshall, L. E., Smith, D. R., Stevens, E. T. & Miller, J. D., Jul 15 2006, Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Single-Dose Rabbit Anti-Thymocyte Globulin Induction With Steroid Avoidance and Calcineurin-Inhibitor Withdrawal in Renal Transplantation

  Stevens, R. B., Grant, W. J., Botha, J. F., Sudan, D. L., Langnas, A. N. & Wrenshall, L. E., Jul 15 2006, Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Successful Steroid Avoidance and Calcineurin-Inhibitor Minimization in Immunological High Risk Renal Transplant Recipients

  Stevens, R. B., Wrenshall, L. E., Grant, W. J., Botha, J. F., Palmer, B., Rigley, T. H., Sudan, D. L. & Langnas, A. N., Jul 15 2006, Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• 2005

  Complete Steroid Avoidance in Renal Transplantation: Extended Daclizumab use in Adult and Pediatric Recipients

  Stevens, R. B., Schmitt, T. M., Reddish, J. C., Rigley, T. H., Hill, B. C., Ravindra, K. V., Grant, W. J., Botha, J. F. & Wrenshall, L. E., May 12 2005, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation

  Colling, C., Stevens, R. B., Lyden, E., Lane, J., Mack-Shipman, L., Wrenshall, L. & Larsen, J., Apr 1 2005, In: Clinical Transplantation. 19, 2, p. 158-161 4 p.

  Research output: Contribution to journal › Article › peer-review

• Immune Function in "True" IL-2 Deficiency

  Wrenshall, L. E., Stevens, E. T., Smith, D. R. & Miller, J. D., May 1 2005, American Journal of Transplantation.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter