Personal profile
About
The overall objective of my research is to understand the interactions between virus and the host defense system occurring between the first 12 to 24 hours of infection (innate immunity) which leads to susceptibility or resistance to disease (acquisition of adaptive immunity). Previously, the research projects under this objective dealt with: a gender-based difference to the pathogenesis of a picornavirus [the D variant of emcephalomyocarditis virus {EMCV-D] and a DNA vaccine for herpes simplex virus, type 1 (HSV-1). My ongoing research involves HSV-1, cytokine signaling pathways, SOCS1/SOCS3 in inflammatory/anti-inflammatory cytokine pathways and cytoskeletal changes in macrophages polarized to the M1 and M2 phenotypes.
Related documents
Research Interests
- Interactions between Viruses and Host Defense Systems
- Acquisition of Adaptive Immunity
Disciplines
- Life Sciences
- Immunology and Infectious Disease
- Medicine and Health Sciences
- Medical Sciences
- Medical Cell Biology
- Neurosciences
- Physiological Processes
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IL-10 and TGF-β Increase Connexin-43 Expression and Membrane Potential of HL-1 Cardiomyocytes Coupled with RAW 264.7 Macrophages
Cox, C. B., Castro, M., Brown, T. L. & Bigley, N. J., Jun 1 2022, In: ImmunoHorizons. 6, 6, p. 334-343 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Adhesion molecules in decompression sickness and ischemia reperfusion injury
Bigley, N. J. & Hull, B. E., Apr 19 2016, Adhesion Molecules. CRC Press, p. 165-181 17 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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SOCS1/3 expression levels in HSV-1-infected, cytokine-polarized and-unpolarized macrophages
Reichard, A. C., Cheemarla, N. R. & Bigley, N. J., Jan 1 2015, In: Journal of Interferon and Cytokine Research. 35, 1, p. 32-41 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Complexity of interferon-γ interactions with HSV-1
Bigley, N. J., 2014, In: Frontiers in Immunology. 5, FEB, Article 15.Research output: Contribution to journal › Review article › peer-review
Open Access -
HSV-1-Induced SOCS-1 Expression in Keratinocytes: Use of a SOCS-1 Antagonist to Block a Novel Mechanism of Viral Immune Evasion
Frey, K. G., Ahmed, C. M. I., Dabelic, R., Jager, L. D., Noon-Song, E. N., Haider, S. M., Johnson, H. M. & Bigley, N. J., Jul 15 2009, In: Journal of Immunology. 183, 2, p. 1253-1262 10 p.Research output: Contribution to journal › Article › peer-review
Open Access