Project Details
Description
ΔNp63α levels and modulates the DNA damage response, apoptosis, therapeutic resistance and squamous cell carcinoma (SCC) tumor progression using a combination of in vitro and in vivo models. This study is relevant to public health because it will provide (1) a mechanistic insight into the development of resistance to
standard treatment modalities for SCC, (2) identify novel therapeutic targets in SCC with elevated TIP60 and ΔNp63α, and (3) assess the efficacy of TIP60 inhibition in sensitizing patient-derived (PDX) cisplatin-resistant head and neck SCC tumors to cisplatin and IR therapy. Thus, the proposed research is relevant to the NIH’s
mission pertaining to the pursuit of fundamental knowledge to enhance health and reduce disability, and specifically to support of research into the mechanism of action of cancer therapeutic agents in both in vitro and in vivo model systems and the identification and validation of new druggable targets.
standard treatment modalities for SCC, (2) identify novel therapeutic targets in SCC with elevated TIP60 and ΔNp63α, and (3) assess the efficacy of TIP60 inhibition in sensitizing patient-derived (PDX) cisplatin-resistant head and neck SCC tumors to cisplatin and IR therapy. Thus, the proposed research is relevant to the NIH’s
mission pertaining to the pursuit of fundamental knowledge to enhance health and reduce disability, and specifically to support of research into the mechanism of action of cancer therapeutic agents in both in vitro and in vivo model systems and the identification and validation of new druggable targets.
| Status | Active |
|---|---|
| Effective start/end date | 9/1/23 → 8/31/28 |