5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept

Nathan R. Kerr; Anna R. Dashtmian; Fereshteh B. Darvishi; Charles D. Brennan; Sindhuja N. Ayyagari; Peter J. Moore; Jose A. Viteri; Meifang Wang; Mark M. Rich; Brian C. Clark; W. David Arnold

doi:10.1007/s11357-025-01519-7

5-HT_2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept

Nathan R. Kerr
, Anna R. Dashtmian
, Fereshteh B. Darvishi
, Charles D. Brennan
, Sindhuja N. Ayyagari
, Peter J. Moore
, Jose A. Viteri
, Meifang Wang
, Mark M. Rich
, Brian C. Clark
, W. David Arnold

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4075-4092
Number of pages	18
Journal	GeroScience
Volume	47
Issue number	3
DOIs	https://doi.org/10.1007/s11357-025-01519-7
State	Published - Jun 2025
Externally published	Yes

ASJC Scopus Subject Areas

Aging
veterinary (miscalleneous)
Complementary and alternative medicine
Geriatrics and Gerontology
Cardiology and Cardiovascular Medicine

Keywords

5-HT receptor agonism
Age-related muscle weakness
Lorcaserin
Motor neuron excitability
Neurotherapeutics
Sarcopenia

Access to Document

10.1007/s11357-025-01519-7

Cite this

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title = "5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept",

keywords = "5-HT receptor agonism, Age-related muscle weakness, Lorcaserin, Motor neuron excitability, Neurotherapeutics, Sarcopenia",

author = "Kerr, \{Nathan R.\} and Dashtmian, \{Anna R.\} and Darvishi, \{Fereshteh B.\} and Brennan, \{Charles D.\} and Ayyagari, \{Sindhuja N.\} and Moore, \{Peter J.\} and Viteri, \{Jose A.\} and Meifang Wang and Rich, \{Mark M.\} and Clark, \{Brian C.\} and \{David Arnold\}, W.",

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doi = "10.1007/s11357-025-01519-7",

language = "English",

volume = "47",

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journal = "GeroScience",

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T1 - 5-HT2C agonism as a neurotherapeutic for sarcopenia

T2 - preclinical proof of concept

AU - Kerr, Nathan R.

AU - Dashtmian, Anna R.

AU - Darvishi, Fereshteh B.

AU - Brennan, Charles D.

AU - Ayyagari, Sindhuja N.

AU - Moore, Peter J.

AU - Viteri, Jose A.

AU - Wang, Meifang

AU - Rich, Mark M.

AU - Clark, Brian C.

AU - David Arnold, W.

N1 - Publisher Copyright: © The Author(s), under exclusive licence to American Aging Association 2025.

PY - 2025/6

Y1 - 2025/6

KW - 5-HT receptor agonism

KW - Age-related muscle weakness

KW - Lorcaserin

KW - Motor neuron excitability

KW - Neurotherapeutics

KW - Sarcopenia

UR - https://www.scopus.com/pages/publications/85217268826

UR - https://www.scopus.com/pages/publications/85217268826#tab=citedBy

U2 - 10.1007/s11357-025-01519-7

DO - 10.1007/s11357-025-01519-7

M3 - Article

C2 - 39825167

AN - SCOPUS:85217268826

SN - 2509-2715

VL - 47

SP - 4075

EP - 4092

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JF - GeroScience

IS - 3