A Computer Model of Mammalian Central CO2 Chemoreception

Mykyta M. Chernov; Robert W. Putnam; James C. Leiter

doi:10.1007/978-0-387-73693-8_52

A Computer Model of Mammalian Central CO₂ Chemoreception

Mykyta M. Chernov, Robert W. Putnam, James C. Leiter

Wright State University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We developed a single compartment model of a mammalian CO ₂ sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO ₂ sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.

Original language	American English
Title of host publication	Integration in Respiratory Control: From Genes to Systems
DOIs	https://doi.org/10.1007/978-0-387-73693-8_52
State	Published - Jan 1 2008

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

Access to Document

10.1007/978-0-387-73693-8_52License: Unspecified

Cite this

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