A Study on Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Cohort Patients

Inski H. Yu; Alive C. Thornton; Timothy N. Crawford; Thein Myint

A Study on Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Cohort Patients

Inski H. Yu, Alive C. Thornton, Timothy N. Crawford, Thein Myint

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

• There are several causes of macrocytosis, such as vitamin B12 or folic acid deficiency, alcoholism, drug-induced conditions such as hydroxyurea, and certain HIV medications such as zidovudine (AZT).

• The mean corpuscular volume (MCV) increased by a mean 3% at week 4, and 14% at 12 weeks after starting AZT. Macrocytosis (MCV >100 fl, normal 79 – 98fL) was present in 78% - 88% in HIV-infected patients treated with AZT.

• There is limited literature on duration of persistence of macrocytosis after AZT is discontinued.

• This study aims to characterize the duration and causes of persistent macrocytosis after discontinuation of AZT.

Original language	American English
Journal	Default journal
State	Published - Jan 1 2015

Disciplines

Community Health and Preventive Medicine
Medicine and Health Sciences
Public Health

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title = "A Study on Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Cohort Patients",

abstract = " • There are several causes of macrocytosis, such as vitamin B12 or folic acid deficiency, alcoholism, drug-induced conditions such as hydroxyurea, and certain HIV medications such as zidovudine (AZT). • The mean corpuscular volume (MCV) increased by a mean 3% at week 4, and 14% at 12 weeks after starting AZT. Macrocytosis (MCV >100 fl, normal 79 – 98fL) was present in 78% - 88% in HIV-infected patients treated with AZT. • There is limited literature on duration of persistence of macrocytosis after AZT is discontinued. • This study aims to characterize the duration and causes of persistent macrocytosis after discontinuation of AZT.",

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AU - Thornton, Alive C.

AU - Crawford, Timothy N.

AU - Myint, Thein

PY - 2015/1/1

Y1 - 2015/1/1

N2 - • There are several causes of macrocytosis, such as vitamin B12 or folic acid deficiency, alcoholism, drug-induced conditions such as hydroxyurea, and certain HIV medications such as zidovudine (AZT). • The mean corpuscular volume (MCV) increased by a mean 3% at week 4, and 14% at 12 weeks after starting AZT. Macrocytosis (MCV >100 fl, normal 79 – 98fL) was present in 78% - 88% in HIV-infected patients treated with AZT. • There is limited literature on duration of persistence of macrocytosis after AZT is discontinued. • This study aims to characterize the duration and causes of persistent macrocytosis after discontinuation of AZT.

AB - • There are several causes of macrocytosis, such as vitamin B12 or folic acid deficiency, alcoholism, drug-induced conditions such as hydroxyurea, and certain HIV medications such as zidovudine (AZT). • The mean corpuscular volume (MCV) increased by a mean 3% at week 4, and 14% at 12 weeks after starting AZT. Macrocytosis (MCV >100 fl, normal 79 – 98fL) was present in 78% - 88% in HIV-infected patients treated with AZT. • There is limited literature on duration of persistence of macrocytosis after AZT is discontinued. • This study aims to characterize the duration and causes of persistent macrocytosis after discontinuation of AZT.

UR - https://corescholar.libraries.wright.edu/familymed/217

UR - https://perma.cc/2JKY-HMM7

M3 - Article

JO - Default journal

JF - Default journal

ER -

A Study on Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Cohort Patients

Abstract

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