Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body

C. Peers; C. N. Wyatt; K. J. Buckler

doi:10.1007/978-1-4615-2572-1_17

Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body

C. Peers, C. N. Wyatt, K. J. Buckler

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Although catecholamines are believed to be the primary chemosensory transmitters, acetylcholine (ACh) is also present in type I cells, and is released during stimulation of the carotid body (Eyzaguirre & Zapata, 1968; Fidone & Gonzalez, 1986). Effects of exogenous ACh vary with species (Fidone et al., 1990), but in the rat and cat, excitatory effects such as increased carotid sinus nerve activity or the stimulation of catecholamine release are observed (Shaw et al., 1989; Kholwadwala & Donnelly, 1992). These effects are mediated by nicotinic ACh receptors (nAChRs). Here, we have examined the actions of nicotinic agonists on isolated type I cells to determine whether nAChRs are present on these cells, and how their activation might lead to the reported excitation of the intact carotid body.

Original language	English
Title of host publication	Arterial Chemoreceptors
Subtitle of host publication	Cell to System
Editors	Ronan G. O’Regan, Philip Nolan, Daniel S. McQueen, David J. Paterson
Publisher	Springer New York
Pages	155-157
Number of pages	3
Volume	360
ISBN (Electronic)	978-1-4615-2572-1
ISBN (Print)	978-0-306-44824-9, 978-1-4613-6099-5
DOIs	https://doi.org/10.1007/978-1-4615-2572-1_17
State	Published - 1994
Event	12th International Meeting on Arterial Chemoreception - Dublin, Ireland Duration: Aug 1 1993 → Aug 1 1993 Conference number: 19

Publication series

Name	Advances in Experimental Medicine and Biology
ISSN (Print)	0065-2598

Conference

Conference	12th International Meeting on Arterial Chemoreception
Country/Territory	Ireland
City	Dublin
Period	8/1/93 → 8/1/93

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

Nicotinic Agonists
Rats
Carotid Body

Disciplines

Medical Cell Biology
Neurosciences

Access to Document

10.1007/978-1-4615-2572-1_17

Cite this

Peers, C., Wyatt, C. N., & Buckler, K. J. (1994). Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body. In R. G. O’Regan, P. Nolan, D. S. McQueen, & D. J. Paterson (Eds.), Arterial Chemoreceptors: Cell to System (Vol. 360, pp. 155-157). (Advances in Experimental Medicine and Biology). Springer New York. https://doi.org/10.1007/978-1-4615-2572-1_17

Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body. / Peers, C.; Wyatt, C. N.; Buckler, K. J.
Arterial Chemoreceptors: Cell to System. ed. / Ronan G. O’Regan; Philip Nolan; Daniel S. McQueen; David J. Paterson. Vol. 360 Springer New York, 1994. p. 155-157 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Peers, C, Wyatt, CN & Buckler, KJ 1994, Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body. in RG O’Regan, P Nolan, DS McQueen & DJ Paterson (eds), Arterial Chemoreceptors: Cell to System. vol. 360, Advances in Experimental Medicine and Biology, Springer New York, pp. 155-157, 12th International Meeting on Arterial Chemoreception, Dublin, Ireland, 8/1/93. https://doi.org/10.1007/978-1-4615-2572-1_17

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abstract = "Although catecholamines are believed to be the primary chemosensory transmitters, acetylcholine (ACh) is also present in type I cells, and is released during stimulation of the carotid body (Eyzaguirre & Zapata, 1968; Fidone & Gonzalez, 1986). Effects of exogenous ACh vary with species (Fidone et al., 1990), but in the rat and cat, excitatory effects such as increased carotid sinus nerve activity or the stimulation of catecholamine release are observed (Shaw et al., 1989; Kholwadwala & Donnelly, 1992). These effects are mediated by nicotinic ACh receptors (nAChRs). Here, we have examined the actions of nicotinic agonists on isolated type I cells to determine whether nAChRs are present on these cells, and how their activation might lead to the reported excitation of the intact carotid body.",

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AB - Although catecholamines are believed to be the primary chemosensory transmitters, acetylcholine (ACh) is also present in type I cells, and is released during stimulation of the carotid body (Eyzaguirre & Zapata, 1968; Fidone & Gonzalez, 1986). Effects of exogenous ACh vary with species (Fidone et al., 1990), but in the rat and cat, excitatory effects such as increased carotid sinus nerve activity or the stimulation of catecholamine release are observed (Shaw et al., 1989; Kholwadwala & Donnelly, 1992). These effects are mediated by nicotinic ACh receptors (nAChRs). Here, we have examined the actions of nicotinic agonists on isolated type I cells to determine whether nAChRs are present on these cells, and how their activation might lead to the reported excitation of the intact carotid body.

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Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body

Abstract

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Keywords

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