TY - JOUR
T1 - Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups
AU - Schiml-Webb, Patricia A.
AU - Deak, Terrence
AU - Greenlee, Tess M.
AU - Maken, Deborah S.
AU - Hennessy, Michael B.
PY - 2006/4/3
Y1 - 2006/4/3
N2 - We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone ( α -MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.
AB - We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone ( α -MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.
KW - Alpha-melanocyte stimulating hormone
KW - Stress-induced sickness
KW - Passive responses
KW - Guinea pig
KW - Maternal attachment
KW - Sickness behavior
UR - https://corescholar.libraries.wright.edu/psychology/91
U2 - 10.1016/j.bbr.2005.08.022
DO - 10.1016/j.bbr.2005.08.022
M3 - Article
C2 - 16214237
VL - 168
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -