Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups

Patricia A. Schiml-Webb; Terrence Deak; Tess M. Greenlee; Deborah S. Maken; Michael B. Hennessy

doi:10.1016/j.bbr.2005.08.022

Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups

Patricia A. Schiml-Webb
, Terrence Deak
, Tess M. Greenlee
, Deborah S. Maken
, Michael B. Hennessy

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone ( α -MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.

Original language	American English
Journal	Behavioural Brain Research
Volume	168
DOIs	https://doi.org/10.1016/j.bbr.2005.08.022
State	Published - Apr 3 2006

Keywords

Alpha-melanocyte stimulating hormone
Stress-induced sickness
Passive responses
Guinea pig
Maternal attachment
Sickness behavior

Disciplines

Psychology
Social and Behavioral Sciences

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10.1016/j.bbr.2005.08.022License: CC BY

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title = "Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups",

abstract = " We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone ( α -MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.",

keywords = "Alpha-melanocyte stimulating hormone, Stress-induced sickness, Passive responses, Guinea pig, Maternal attachment, Sickness behavior",

author = "Schiml-Webb, \{Patricia A.\} and Terrence Deak and Greenlee, \{Tess M.\} and Maken, \{Deborah S.\} and Hennessy, \{Michael B.\}",

year = "2006",

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language = "American English",

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journal = "Behavioural Brain Research",

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AU - Schiml-Webb, Patricia A.

AU - Deak, Terrence

AU - Greenlee, Tess M.

AU - Maken, Deborah S.

AU - Hennessy, Michael B.

PY - 2006/4/3

Y1 - 2006/4/3

N2 - We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone ( α -MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.

AB - We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone ( α -MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.

KW - Alpha-melanocyte stimulating hormone

KW - Stress-induced sickness

KW - Passive responses

KW - Guinea pig

KW - Maternal attachment

KW - Sickness behavior

UR - https://corescholar.libraries.wright.edu/psychology/91

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DO - 10.1016/j.bbr.2005.08.022

M3 - Article

C2 - 16214237

VL - 168

JO - Behavioural Brain Research

JF - Behavioural Brain Research

ER -

Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups

Abstract

Keywords

Disciplines

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