Amikacin Pharmacokinetics in Pediatric Patients with Burn Injuries Compared to Those with Oncology Conditions

Xiaoxi Liu; Anne Smits; Tian Yu; Stephanie Wead; Alice Neely; Richard J. Kagan; Daniel P. Healy; Karel Allegaert; Catherine M.T. Sherwin

Amikacin Pharmacokinetics in Pediatric Patients with Burn Injuries Compared to Those with Oncology Conditions

Xiaoxi Liu, Anne Smits, Tian Yu, Stephanie Wead, Alice Neely, Richard J. Kagan, Daniel P. Healy, Karel Allegaert, Catherine M.T. Sherwin

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

Physiologic changes due to disease status can lead to highly variable pharmacokinetics (PK) of amikacin in children. Therefore, considerations should be given when determining optimal amikacin does for patients with a specific diseases. Improved understanding of factors influencing PD can allow for the optimizing of dosage regimens to reduce adverse effects.

The aim of the study was to undertake a comparative pharmacometic analysis of amikacin use in pediatric patients with burn injuries verses those with oncology conditions.

Original language	American English
Journal	Default journal
State	Published - Jan 1 2016

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Medical Specialties
Medicine and Health Sciences
Pediatrics

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Amikacin Pharmacokinetics in Pediatric Patients with Burn InjurieFinal published version, 527 KBLicense: Unspecified

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title = "Amikacin Pharmacokinetics in Pediatric Patients with Burn Injuries Compared to Those with Oncology Conditions",

abstract = " Physiologic changes due to disease status can lead to highly variable pharmacokinetics (PK) of amikacin in children. Therefore, considerations should be given when determining optimal amikacin does for patients with a specific diseases. Improved understanding of factors influencing PD can allow for the optimizing of dosage regimens to reduce adverse effects. The aim of the study was to undertake a comparative pharmacometic analysis of amikacin use in pediatric patients with burn injuries verses those with oncology conditions.",

author = "Xiaoxi Liu and Anne Smits and Tian Yu and Stephanie Wead and Alice Neely and Kagan, {Richard J.} and Healy, {Daniel P.} and Karel Allegaert and Sherwin, {Catherine M.T.}",

year = "2016",

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day = "1",

language = "American English",

journal = "Default journal",

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TY - JOUR

T1 - Amikacin Pharmacokinetics in Pediatric Patients with Burn Injuries Compared to Those with Oncology Conditions

AU - Liu, Xiaoxi

AU - Smits, Anne

AU - Yu, Tian

AU - Wead, Stephanie

AU - Neely, Alice

AU - Kagan, Richard J.

AU - Healy, Daniel P.

AU - Allegaert, Karel

AU - Sherwin, Catherine M.T.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Physiologic changes due to disease status can lead to highly variable pharmacokinetics (PK) of amikacin in children. Therefore, considerations should be given when determining optimal amikacin does for patients with a specific diseases. Improved understanding of factors influencing PD can allow for the optimizing of dosage regimens to reduce adverse effects. The aim of the study was to undertake a comparative pharmacometic analysis of amikacin use in pediatric patients with burn injuries verses those with oncology conditions.

AB - Physiologic changes due to disease status can lead to highly variable pharmacokinetics (PK) of amikacin in children. Therefore, considerations should be given when determining optimal amikacin does for patients with a specific diseases. Improved understanding of factors influencing PD can allow for the optimizing of dosage regimens to reduce adverse effects. The aim of the study was to undertake a comparative pharmacometic analysis of amikacin use in pediatric patients with burn injuries verses those with oncology conditions.

UR - https://corescholar.libraries.wright.edu/pediatrics/321

M3 - Article

JO - Default journal

JF - Default journal

ER -

Amikacin Pharmacokinetics in Pediatric Patients with Burn Injuries Compared to Those with Oncology Conditions

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