TY - JOUR
T1 - Anti-Inflammatory Agents Attenuate the Passive Responses of Guinea Pig Pups: Evidence for Stress-Induced Sickness Behavior During Maternal Separation
AU - Hennessy, Michael B.
AU - Schiml-Webb, Patricia A.
AU - Miller, Emily E.
AU - Maken, Deborah S.
AU - Bullinger, Katie L.
AU - Deak, Terrence
PY - 2007/6/1
Y1 - 2007/6/1
N2 - A previous study found that intracerebroventricular (ICV) infusion of 25 μg of α-MSH reduced the passive responses (crouched stance, eye-closing, piloerection) of guinea pig pups during a 3-h isolation in a novel environment. Because α-MSH has broad anti-inflammatory properties, the results suggested that proinflammatory factors play a role in mediating the behavior of isolated infants. The present study further investigated this possibility. In Experiment 1, injection of lipopolysacchride (LPS) increased the number of 60-s intervals in which pups expressed the same three responses during a 1-h test, and ICV infusion of α-MSH significantly reduced the effect of LPS on crouching and piloerection. In Experiment 2, the prostaglandin synthesis inhibitor indomethacin (10 mg/kg) reduced the number of 60-s intervals in which pups exhibited both crouching and the full suite of passive responses during a 3-h isolation in a novel environment. Together these results provide further support for the hypothesis that the passive behaviors exhibited during prolonged isolation are “stress-induced sickness behaviors” mediated by proinflammatory factors.
AB - A previous study found that intracerebroventricular (ICV) infusion of 25 μg of α-MSH reduced the passive responses (crouched stance, eye-closing, piloerection) of guinea pig pups during a 3-h isolation in a novel environment. Because α-MSH has broad anti-inflammatory properties, the results suggested that proinflammatory factors play a role in mediating the behavior of isolated infants. The present study further investigated this possibility. In Experiment 1, injection of lipopolysacchride (LPS) increased the number of 60-s intervals in which pups expressed the same three responses during a 1-h test, and ICV infusion of α-MSH significantly reduced the effect of LPS on crouching and piloerection. In Experiment 2, the prostaglandin synthesis inhibitor indomethacin (10 mg/kg) reduced the number of 60-s intervals in which pups exhibited both crouching and the full suite of passive responses during a 3-h isolation in a novel environment. Together these results provide further support for the hypothesis that the passive behaviors exhibited during prolonged isolation are “stress-induced sickness behaviors” mediated by proinflammatory factors.
KW - sickness behaviors
KW - acute phase response
KW - inflammation
KW - maternal separation
KW - isolation
KW - guinea pig
UR - https://corescholar.libraries.wright.edu/psychology/87
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955689/pdf/nihms25365.pdf
U2 - 10.1016/j.psyneuen.2007.03.004
DO - 10.1016/j.psyneuen.2007.03.004
M3 - Article
C2 - 17462831
VL - 32
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -