Carbamazepine-Lithium Toxicity in Brain-Damaged Adolescents

Dean Parmelee; G J O'Shanick

doi:10.3109/02699058809150900

Carbamazepine-Lithium Toxicity in Brain-Damaged Adolescents

Dean Parmelee, G J O'Shanick

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

For several years carbamazepine has been used to treat intractable mania and it is frequently used in combination with lithium. Reports of toxicity have appeared in the past 2 years and some risk factors have been suggested. This paper reports four cases of brain-damaged adolescents treated with carbamazepine and lithium for both seizure and behaviour control who developed this reported neurotoxic phenomenon.

Original language	American English
Journal	Brain Injury
Volume	2
DOIs	https://doi.org/10.3109/02699058809150900
State	Published - Oct 1 1988

Keywords

Adolescent
Brain Damage
Carbamazepine -- Adverse Effects
Carbamazepine -- Therapeutic Use
Chronic -- Drug Therapy
Combination
Dose-Response Relationship -- Drug
Drug Therapy
Female
Humans
Lithium -- Adverse Effects
Lithium -- Therapeutic Use
Lithium Carbonate
Male
Nervous System Diseases -- Chemically Induced
Neurocognitive Disorders -- Drug Therapy
Substance Related Disorders -- Etiology

Disciplines

Medical Education
Medicine and Health Sciences
Pediatrics

Access to Document

10.3109/02699058809150900License: Unspecified

Cite this

@article{b128139ad7c74830ae1707fbda138183,

title = "Carbamazepine-Lithium Toxicity in Brain-Damaged Adolescents",

abstract = " For several years carbamazepine has been used to treat intractable mania and it is frequently used in combination with lithium. Reports of toxicity have appeared in the past 2 years and some risk factors have been suggested. This paper reports four cases of brain-damaged adolescents treated with carbamazepine and lithium for both seizure and behaviour control who developed this reported neurotoxic phenomenon.",

keywords = "Adolescent, Brain Damage, Carbamazepine -- Adverse Effects, Carbamazepine -- Therapeutic Use, Chronic -- Drug Therapy, Combination, Dose-Response Relationship -- Drug, Drug Therapy, Female, Humans, Lithium -- Adverse Effects, Lithium -- Therapeutic Use, Lithium Carbonate, Male, Nervous System Diseases -- Chemically Induced, Neurocognitive Disorders -- Drug Therapy, Substance Related Disorders -- Etiology",

author = "Dean Parmelee and O'Shanick, {G J}",

year = "1988",

month = oct,

day = "1",

doi = "10.3109/02699058809150900",

language = "American English",

volume = "2",

journal = "Brain Injury",

}

TY - JOUR

T1 - Carbamazepine-Lithium Toxicity in Brain-Damaged Adolescents

AU - Parmelee, Dean

AU - O'Shanick, G J

PY - 1988/10/1

Y1 - 1988/10/1

N2 - For several years carbamazepine has been used to treat intractable mania and it is frequently used in combination with lithium. Reports of toxicity have appeared in the past 2 years and some risk factors have been suggested. This paper reports four cases of brain-damaged adolescents treated with carbamazepine and lithium for both seizure and behaviour control who developed this reported neurotoxic phenomenon.

AB - For several years carbamazepine has been used to treat intractable mania and it is frequently used in combination with lithium. Reports of toxicity have appeared in the past 2 years and some risk factors have been suggested. This paper reports four cases of brain-damaged adolescents treated with carbamazepine and lithium for both seizure and behaviour control who developed this reported neurotoxic phenomenon.

KW - Adolescent

KW - Brain Damage

KW - Carbamazepine -- Adverse Effects

KW - Carbamazepine -- Therapeutic Use

KW - Chronic -- Drug Therapy

KW - Combination

KW - Dose-Response Relationship -- Drug

KW - Drug Therapy

KW - Female

KW - Humans

KW - Lithium -- Adverse Effects

KW - Lithium -- Therapeutic Use

KW - Lithium Carbonate

KW - Male

KW - Nervous System Diseases -- Chemically Induced

KW - Neurocognitive Disorders -- Drug Therapy

KW - Substance Related Disorders -- Etiology

UR - https://corescholar.libraries.wright.edu/med_education/72

U2 - 10.3109/02699058809150900

DO - 10.3109/02699058809150900

M3 - Article

VL - 2

JO - Brain Injury

JF - Brain Injury

ER -

Carbamazepine-Lithium Toxicity in Brain-Damaged Adolescents

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Cite this