Cell Volume Modifies an ATP-Sensitive Anion Conductance in Cultured Hippocampal Astrocytes

Guangze Li, James E. Olson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Maintenance and regulation of cell volume are fundamental physiological processes. Previous data showed that swelling of cultured rat astrocytes in 220 mOsm medium activates an outwardly rectifying anion current. This current is considered to be mediated by a chloride channel that also conducts the amino acid taurine. The mechanism by which cell swelling activates chloride conductance is not clear; however, recent studies support an important role for extracellular ATP in swelling-induced amino acid efflux and anion current activation. Herein, we will examine the interaction between volume and ATP in cultured rat hippocampal astrocytes.
Original languageEnglish
Title of host publicationCell Volume and Signaling
EditorsPeter K. Lauf, Norma C. Adragna
PublisherSpringer Science+Business Media
Chapter46
Pages405-406
Number of pages2
Volume559
ISBN (Electronic)0-387-23299-0
DOIs
StatePublished - 2005
Event2003 Dayton International Symposium on Cell Volume Regulation and Signaling - Datyon, United States
Duration: Jan 1 2003 → …

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Conference

Conference2003 Dayton International Symposium on Cell Volume Regulation and Signaling
Country/TerritoryUnited States
CityDatyon
Period1/1/03 → …

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

Keywords

  • Cell volume
  • ATP-sensitive anion conductance
  • Hippocampal astrocytes

Disciplines

  • Neurosciences
  • Neurology

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