Circulating Cellular and Humoral Elements of Immune Function Following Splenic Arterial Embolisation or Splenectomy in Trauma Patients

Mbaga S. Walusimbi; Kathleen M. Dominguez; Jean J. Sands; Ronald J. Markert; Mary C. McCarthy

doi:10.1016/j.injury.2011.05.028

Circulating Cellular and Humoral Elements of Immune Function Following Splenic Arterial Embolisation or Splenectomy in Trauma Patients

Mbaga S. Walusimbi, Kathleen M. Dominguez, Jean J. Sands, Ronald J. Markert, Mary C. McCarthy

Research output: Contribution to journal › Article › peer-review

Abstract

<p> <h4 id="x-x-x-absSec_1"> Background </h4> <p id="x-x-x-spar0005"> Splenectomy impairs the ability to combat infection, especially with encapsulated organisms. However, there is limited understanding of the impact of splenic arterial embolisation on immune function. Our hypothesis was that embolisation would not impair systemic immune function. This study examines elements of cellular and humoral immunity in patients undergoing splenic embolisation or splenectomy for trauma. <h4 id="x-x-x-absSec_2"> Patients and methods </h4> <p id="x-x-x-spar0010"> Splenic embolisation (SE) and splenectomy patients (S) were compared to blunt trauma patients without splenic injury (NS). Lymphocyte counts, natural-killer cells, serum complement (C3, C4), and properdin levels were assayed. <h4 id="x-x-x-absSec_3"> Results </h4> <p id="x-x-x-spar0015"> No significant differences in total, helper, or suppressor T-lymphocytes, complement (C3, C4), or properdin were found. B-lymphocyte counts were higher in S (602 ± 445 cells/mm <sup> 3 </sup> ) than SE (238 ± 114 cells/mm <sup> 3 </sup> ) or NS (293 ± 153 cells/mm <sup> 3 </sup> ) ( <em> p </em> = .003 for pairwise comparisons). S also had more natural killer T-cells than NS (325 ± 170 cells/mm <sup> 3 </sup> vs. 174 ± 116 cells/mm <sup> 3 </sup> , <em> p </em> = .004). <h4 id="x-x-x-absSec_4"> Conclusion </h4> <p id="x-x-x-spar0020"> Splenic embolisation does not alter the measured immunologic parameters. The absence of sensitive markers for splenic immune function limits the ability to assess the impact of embolisation for trauma. </p> </p> </p> </p></p>

Original language	American English
Journal	Injury
Volume	43
DOIs	https://doi.org/10.1016/j.injury.2011.05.028
State	Published - Feb 1 2012

Keywords

Splenic Embolisation
Splenic Immunologic Function
Splenectomy
Splenic Trauma

Disciplines

Medical Specialties
Medicine and Health Sciences
Surgery

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10.1016/j.injury.2011.05.028License: CC BY

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@article{7e0b5543119a4c26afaca5b84a7e8ca7,

title = "Circulating Cellular and Humoral Elements of Immune Function Following Splenic Arterial Embolisation or Splenectomy in Trauma Patients",

abstract = " Background Splenectomy impairs the ability to combat infection, especially with encapsulated organisms. However, there is limited understanding of the impact of splenic arterial embolisation on immune function. Our hypothesis was that embolisation would not impair systemic immune function. This study examines elements of cellular and humoral immunity in patients undergoing splenic embolisation or splenectomy for trauma. Patients and methods Splenic embolisation (SE) and splenectomy patients (S) were compared to blunt trauma patients without splenic injury (NS). Lymphocyte counts, natural-killer cells, serum complement (C3, C4), and properdin levels were assayed. Results No significant differences in total, helper, or suppressor T-lymphocytes, complement (C3, C4), or properdin were found. B-lymphocyte counts were higher in S (602 ± 445 cells/mm 3 ) than SE (238 ± 114 cells/mm 3 ) or NS (293 ± 153 cells/mm 3 ) ( p = .003 for pairwise comparisons). S also had more natural killer T-cells than NS (325 ± 170 cells/mm 3 vs. 174 ± 116 cells/mm 3 , p = .004). Conclusion Splenic embolisation does not alter the measured immunologic parameters. The absence of sensitive markers for splenic immune function limits the ability to assess the impact of embolisation for trauma. ",

keywords = "Splenic Embolisation, Splenic Immunologic Function, Splenectomy, Splenic Trauma",

author = "Walusimbi, {Mbaga S.} and Dominguez, {Kathleen M.} and Sands, {Jean J.} and Markert, {Ronald J.} and McCarthy, {Mary C.}",

year = "2012",

month = feb,

day = "1",

doi = "10.1016/j.injury.2011.05.028",

language = "American English",

volume = "43",

journal = "Injury",

}

TY - JOUR

T1 - Circulating Cellular and Humoral Elements of Immune Function Following Splenic Arterial Embolisation or Splenectomy in Trauma Patients

AU - Walusimbi, Mbaga S.

AU - Dominguez, Kathleen M.

AU - Sands, Jean J.

AU - Markert, Ronald J.

AU - McCarthy, Mary C.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Background Splenectomy impairs the ability to combat infection, especially with encapsulated organisms. However, there is limited understanding of the impact of splenic arterial embolisation on immune function. Our hypothesis was that embolisation would not impair systemic immune function. This study examines elements of cellular and humoral immunity in patients undergoing splenic embolisation or splenectomy for trauma. Patients and methods Splenic embolisation (SE) and splenectomy patients (S) were compared to blunt trauma patients without splenic injury (NS). Lymphocyte counts, natural-killer cells, serum complement (C3, C4), and properdin levels were assayed. Results No significant differences in total, helper, or suppressor T-lymphocytes, complement (C3, C4), or properdin were found. B-lymphocyte counts were higher in S (602 ± 445 cells/mm 3 ) than SE (238 ± 114 cells/mm 3 ) or NS (293 ± 153 cells/mm 3 ) ( p = .003 for pairwise comparisons). S also had more natural killer T-cells than NS (325 ± 170 cells/mm 3 vs. 174 ± 116 cells/mm 3 , p = .004). Conclusion Splenic embolisation does not alter the measured immunologic parameters. The absence of sensitive markers for splenic immune function limits the ability to assess the impact of embolisation for trauma.

AB - Background Splenectomy impairs the ability to combat infection, especially with encapsulated organisms. However, there is limited understanding of the impact of splenic arterial embolisation on immune function. Our hypothesis was that embolisation would not impair systemic immune function. This study examines elements of cellular and humoral immunity in patients undergoing splenic embolisation or splenectomy for trauma. Patients and methods Splenic embolisation (SE) and splenectomy patients (S) were compared to blunt trauma patients without splenic injury (NS). Lymphocyte counts, natural-killer cells, serum complement (C3, C4), and properdin levels were assayed. Results No significant differences in total, helper, or suppressor T-lymphocytes, complement (C3, C4), or properdin were found. B-lymphocyte counts were higher in S (602 ± 445 cells/mm 3 ) than SE (238 ± 114 cells/mm 3 ) or NS (293 ± 153 cells/mm 3 ) ( p = .003 for pairwise comparisons). S also had more natural killer T-cells than NS (325 ± 170 cells/mm 3 vs. 174 ± 116 cells/mm 3 , p = .004). Conclusion Splenic embolisation does not alter the measured immunologic parameters. The absence of sensitive markers for splenic immune function limits the ability to assess the impact of embolisation for trauma.

KW - Splenic Embolisation

KW - Splenic Immunologic Function

KW - Splenectomy

KW - Splenic Trauma

UR - https://corescholar.libraries.wright.edu/surg/181

U2 - 10.1016/j.injury.2011.05.028

DO - 10.1016/j.injury.2011.05.028

M3 - Article

C2 - 21696725

VL - 43

JO - Injury

JF - Injury

ER -

Circulating Cellular and Humoral Elements of Immune Function Following Splenic Arterial Embolisation or Splenectomy in Trauma Patients

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