Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial

Michael D. Kappelman; David A. Wohl; Hans H. Herfarth; Ann M. Firestine; Jeremy Adler; Rana F. Ammoury; Jeanine E. Aronow; Dorsey M. Bass; Julie A. Bass; Keith Benkov; Catalina Berenblum Tobi; Margie E. Boccieri; Brendan M. Boyle; William B. Brinkman; Jose M. Cabera; Kelly Chun; Richard B. Colletti; Cassandra M. Dodds; Jill M. Dorsey; Dawn R. Ebach; Edurne Entrena; Christopher B. Forrest; Joseph A. Galanko; John E. Grunow; Ajay S. Gulati; Anastasia Ivanova; Traci W. Jester; Jess L. Kaplan; Subra Kugathasan; Mark E. Kusek; Ian H. Leibowitz; Tiffany M. Linville; Ellen A. Lipstein; Peter A. Margolis; Phillip Minar; Zarela Molle-Rios; Jonathan Moses; Kelly K. Olano; Lourdes Osaba; Pablo J. Palomo; Helen Pappa; K. T. Park; Dinesh S. Pashankar; Lisa Pitch; Michelle Robinson; Charles M. Samson; Kelly C. Sandberg; Julia R. Schuchard; Michael Seid; Kimberly A. Shelly; Steven J. Steiner; Jennifer A. Strople; Jillian S. Sullivan; Jeanne Tung; Prateek Wali; Michael Zikry; Morris Weinberger; Shehzad A. Saeed; Athos Bousvaros

doi:10.1053/j.gastro.2023.03.224

Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial

Michael D. Kappelman
, David A. Wohl
, Hans H. Herfarth
, Ann M. Firestine
, Jeremy Adler
, Rana F. Ammoury
, Jeanine E. Aronow
, Dorsey M. Bass
, Julie A. Bass
, Keith Benkov
, Catalina Berenblum Tobi
, Margie E. Boccieri
, Brendan M. Boyle
, William B. Brinkman
, Jose M. Cabera
, Kelly Chun
, Richard B. Colletti
, Cassandra M. Dodds
, Jill M. Dorsey
, Dawn R. Ebach

Edurne Entrena, Christopher B. Forrest, Joseph A. Galanko, John E. Grunow, Ajay S. Gulati, Anastasia Ivanova, Traci W. Jester, Jess L. Kaplan, Subra Kugathasan, Mark E. Kusek, Ian H. Leibowitz, Tiffany M. Linville, Ellen A. Lipstein, Peter A. Margolis, Phillip Minar, Zarela Molle-Rios, Jonathan Moses, Kelly K. Olano, Lourdes Osaba, Pablo J. Palomo, Helen Pappa, K. T. Park, Dinesh S. Pashankar, Lisa Pitch, Michelle Robinson, Charles M. Samson, Kelly C. Sandberg, Julia R. Schuchard, Michael Seid, Kimberly A. Shelly, Steven J. Steiner, Jennifer A. Strople, Jillian S. Sullivan, Jeanne Tung, Prateek Wali, Michael Zikry, Morris Weinberger, Shehzad A. Saeed, Athos Bousvaros

Pediatrics

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	149-161.e7
Journal	Gastroenterology
Volume	165
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2023.03.224
State	Published - Jul 2023

ASJC Scopus Subject Areas

Hepatology
Gastroenterology

Keywords

Adalimumab
Anti-Tumor Necrosis Factor–α
Children
Crohn's Disease
Infliximab
Methotrexate

Access to Document

10.1053/j.gastro.2023.03.224

Cite this

Kappelman, M. D., Wohl, D. A., Herfarth, H. H., Firestine, A. M., Adler, J., Ammoury, R. F., Aronow, J. E., Bass, D. M., Bass, J. A., Benkov, K., Tobi, C. B., Boccieri, M. E., Boyle, B. M., Brinkman, W. B., Cabera, J. M., Chun, K., Colletti, R. B., Dodds, C. M., Dorsey, J. M., ... Bousvaros, A. (2023). Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial. Gastroenterology, 165(1), 149-161.e7. https://doi.org/10.1053/j.gastro.2023.03.224

Kappelman, MD, Wohl, DA, Herfarth, HH, Firestine, AM, Adler, J, Ammoury, RF, Aronow, JE, Bass, DM, Bass, JA, Benkov, K, Tobi, CB, Boccieri, ME, Boyle, BM, Brinkman, WB, Cabera, JM, Chun, K, Colletti, RB, Dodds, CM, Dorsey, JM, Ebach, DR, Entrena, E, Forrest, CB, Galanko, JA, Grunow, JE, Gulati, AS, Ivanova, A, Jester, TW, Kaplan, JL, Kugathasan, S, Kusek, ME, Leibowitz, IH, Linville, TM, Lipstein, EA, Margolis, PA, Minar, P, Molle-Rios, Z, Moses, J, Olano, KK, Osaba, L, Palomo, PJ, Pappa, H, Park, KT, Pashankar, DS, Pitch, L, Robinson, M, Samson, CM, Sandberg, KC, Schuchard, JR, Seid, M, Shelly, KA, Steiner, SJ, Strople, JA, Sullivan, JS, Tung, J, Wali, P, Zikry, M, Weinberger, M, Saeed, SA & Bousvaros, A 2023, 'Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial', Gastroenterology, vol. 165, no. 1, pp. 149-161.e7. https://doi.org/10.1053/j.gastro.2023.03.224

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title = "Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial",

keywords = "Adalimumab, Anti-Tumor Necrosis Factor–α, Children, Crohn's Disease, Infliximab, Methotrexate",

author = "Kappelman, \{Michael D.\} and Wohl, \{David A.\} and Herfarth, \{Hans H.\} and Firestine, \{Ann M.\} and Jeremy Adler and Ammoury, \{Rana F.\} and Aronow, \{Jeanine E.\} and Bass, \{Dorsey M.\} and Bass, \{Julie A.\} and Keith Benkov and Tobi, \{Catalina Berenblum\} and Boccieri, \{Margie E.\} and Boyle, \{Brendan M.\} and Brinkman, \{William B.\} and Cabera, \{Jose M.\} and Kelly Chun and Colletti, \{Richard B.\} and Dodds, \{Cassandra M.\} and Dorsey, \{Jill M.\} and Ebach, \{Dawn R.\} and Edurne Entrena and Forrest, \{Christopher B.\} and Galanko, \{Joseph A.\} and Grunow, \{John E.\} and Gulati, \{Ajay S.\} and Anastasia Ivanova and Jester, \{Traci W.\} and Kaplan, \{Jess L.\} and Subra Kugathasan and Kusek, \{Mark E.\} and Leibowitz, \{Ian H.\} and Linville, \{Tiffany M.\} and Lipstein, \{Ellen A.\} and Margolis, \{Peter A.\} and Phillip Minar and Zarela Molle-Rios and Jonathan Moses and Olano, \{Kelly K.\} and Lourdes Osaba and Palomo, \{Pablo J.\} and Helen Pappa and Park, \{K. T.\} and Pashankar, \{Dinesh S.\} and Lisa Pitch and Michelle Robinson and Samson, \{Charles M.\} and Sandberg, \{Kelly C.\} and Schuchard, \{Julia R.\} and Michael Seid and Shelly, \{Kimberly A.\} and Steiner, \{Steven J.\} and Strople, \{Jennifer A.\} and Sullivan, \{Jillian S.\} and Jeanne Tung and Prateek Wali and Michael Zikry and Morris Weinberger and Saeed, \{Shehzad A.\} and Athos Bousvaros",

note = "Publisher Copyright: {\textcopyright} 2023 AGA Institute",

year = "2023",

month = jul,

doi = "10.1053/j.gastro.2023.03.224",

language = "English",

volume = "165",

pages = "149--161.e7",

journal = "Gastroenterology",

issn = "0016-5085",

number = "1",

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TY - JOUR

T1 - Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease

T2 - A Pragmatic Randomized Trial

AU - Kappelman, Michael D.

AU - Wohl, David A.

AU - Herfarth, Hans H.

AU - Firestine, Ann M.

AU - Adler, Jeremy

AU - Ammoury, Rana F.

AU - Aronow, Jeanine E.

AU - Bass, Dorsey M.

AU - Bass, Julie A.

AU - Benkov, Keith

AU - Tobi, Catalina Berenblum

AU - Boccieri, Margie E.

AU - Boyle, Brendan M.

AU - Brinkman, William B.

AU - Cabera, Jose M.

AU - Chun, Kelly

AU - Colletti, Richard B.

AU - Dodds, Cassandra M.

AU - Dorsey, Jill M.

AU - Ebach, Dawn R.

AU - Entrena, Edurne

AU - Forrest, Christopher B.

AU - Galanko, Joseph A.

AU - Grunow, John E.

AU - Gulati, Ajay S.

AU - Ivanova, Anastasia

AU - Jester, Traci W.

AU - Kaplan, Jess L.

AU - Kugathasan, Subra

AU - Kusek, Mark E.

AU - Leibowitz, Ian H.

AU - Linville, Tiffany M.

AU - Lipstein, Ellen A.

AU - Margolis, Peter A.

AU - Minar, Phillip

AU - Molle-Rios, Zarela

AU - Moses, Jonathan

AU - Olano, Kelly K.

AU - Osaba, Lourdes

AU - Palomo, Pablo J.

AU - Pappa, Helen

AU - Park, K. T.

AU - Pashankar, Dinesh S.

AU - Pitch, Lisa

AU - Robinson, Michelle

AU - Samson, Charles M.

AU - Sandberg, Kelly C.

AU - Schuchard, Julia R.

AU - Seid, Michael

AU - Shelly, Kimberly A.

AU - Steiner, Steven J.

AU - Strople, Jennifer A.

AU - Sullivan, Jillian S.

AU - Tung, Jeanne

AU - Wali, Prateek

AU - Zikry, Michael

AU - Weinberger, Morris

AU - Saeed, Shehzad A.

AU - Bousvaros, Athos

PY - 2023/7

Y1 - 2023/7

KW - Adalimumab

KW - Anti-Tumor Necrosis Factor–α

KW - Children

KW - Crohn's Disease

KW - Infliximab

KW - Methotrexate

UR - https://www.scopus.com/pages/publications/85160621150

UR - https://www.scopus.com/pages/publications/85160621150#tab=citedBy

U2 - 10.1053/j.gastro.2023.03.224

DO - 10.1053/j.gastro.2023.03.224

M3 - Article

C2 - 37004887

AN - SCOPUS:85160621150

SN - 0016-5085

VL - 165

SP - 149-161.e7

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial

ASJC Scopus Subject Areas

Keywords

Access to Document

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