Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold

Elisa Liardo, Anh Tuan Pham, Amanda F. Ghilardi, Tetyana Zhelay, Kalina Szteyn, Naga Lakshmi Gandi, Anil Ekkati, Steffi Koerner, J. Ashot Kozak, Lijun Sun

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number116805
JournalEuropean Journal of Medicinal Chemistry
Volume278
DOIs
StatePublished - Nov 15 2024
Externally publishedYes

ASJC Scopus Subject Areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Autoimmune diseases
  • Calcium release activated calcium (CRAC) channel
  • Nuclear factor of activated T cells (NFAT)
  • Orai blockers
  • Store-operated calcium entry (SOCE)
  • Transient receptor potential melastatin 4 and 7 (TRPM4 and TRPM7) channels

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