Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?

C. N. Wyatt; P. Kumar; P. Aley; C. Peers; D. G. Hardie; A. M. Evans

doi:10.1007/0-387-31311-7_29

Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?

C. N. Wyatt, P. Kumar, P. Aley, C. Peers, D. G. Hardie, A. M. Evans

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The carotid bodies are the primary peripheral chemoreceptors. They respond to a fall in blood pO2, a rise in blood pCO2 and consequent fall in pH by releasing neurotransmitters. These increase the firing frequency of the carotid sinus nerves which then correct the pattern of breathing via an action at the brainstem. It is now generally accepted that the type 1 or glomus cells are the chemosensory element within the carotid body. However, the precise mechanism by which a fall in pO2 excites the neurotransmitter rich type 1 cells has been the subject of hearty debate for decades now.

Original language	English
Title of host publication	The Arterial Chemoreceptors
Editors	Yoshiaki Hayashida, Constancio Gonzalez, Hisatake Kondo
Publisher	Springer New York
Pages	191-196
Number of pages	6
ISBN (Electronic)	978-0-387-31311-5
ISBN (Print)	9780387313108, 978-1-4899-7736-6
DOIs	https://doi.org/10.1007/0-387-31311-7_29
State	Published - 2006

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	580
ISSN (Print)	0065-2598

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

Carotid Body/*metabolism
Cell Hypoxia/*physiology
Multienzyme Complexes/*metabolism
Protein Serine-Threonine Kinases/*metabolism
AMP-Activated Protein Kinases
Aminoimidazole Carboxamide/analogs & derivatives
Aminoimidazole Carboxamide/pharmacology
Animals
Animals, Newborn
Calcium Signaling/drug effects
Carotid Body/cytology
Carotid Body/drug effects
Chemoreceptor Cells/metabolism
Electrophysiology
Immunohistochemistry
In Vitro Techniques
Membrane Potentials/drug effects
Models, Neurological
Oxidative Phosphorylation/drug effects
Rats
Ribonucleotides/pharmacology

Disciplines

Molecular and Cellular Neuroscience
Neurosciences

Access to Document

10.1007/0-387-31311-7_29

Cite this

Wyatt, C. N., Kumar, P., Aley, P., Peers, C., Hardie, D. G., & Evans, A. M. (2006). Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? In Y. Hayashida, C. Gonzalez, & H. Kondo (Eds.), The Arterial Chemoreceptors (pp. 191-196). (Advances in Experimental Medicine and Biology; Vol. 580). Springer New York. https://doi.org/10.1007/0-387-31311-7_29

Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? / Wyatt, C. N.; Kumar, P.; Aley, P. et al.
The Arterial Chemoreceptors. ed. / Yoshiaki Hayashida; Constancio Gonzalez; Hisatake Kondo. Springer New York, 2006. p. 191-196 (Advances in Experimental Medicine and Biology; Vol. 580).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wyatt, CN, Kumar, P, Aley, P, Peers, C, Hardie, DG & Evans, AM 2006, Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? in Y Hayashida, C Gonzalez & H Kondo (eds), The Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol. 580, Springer New York, pp. 191-196. https://doi.org/10.1007/0-387-31311-7_29

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title = "Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?",

abstract = "The carotid bodies are the primary peripheral chemoreceptors. They respond to a fall in blood pO2, a rise in blood pCO2 and consequent fall in pH by releasing neurotransmitters. These increase the firing frequency of the carotid sinus nerves which then correct the pattern of breathing via an action at the brainstem. It is now generally accepted that the type 1 or glomus cells are the chemosensory element within the carotid body. However, the precise mechanism by which a fall in pO2 excites the neurotransmitter rich type 1 cells has been the subject of hearty debate for decades now.",

keywords = "Carotid Body/*metabolism, Cell Hypoxia/*physiology, Multienzyme Complexes/*metabolism, Protein Serine-Threonine Kinases/*metabolism, AMP-Activated Protein Kinases, Aminoimidazole Carboxamide/analogs & derivatives, Aminoimidazole Carboxamide/pharmacology, Animals, Animals, Newborn, Calcium Signaling/drug effects, Carotid Body/cytology, Carotid Body/drug effects, Chemoreceptor Cells/metabolism, Electrophysiology, Immunohistochemistry, In Vitro Techniques, Membrane Potentials/drug effects, Models, Neurological, Oxidative Phosphorylation/drug effects, Rats, Ribonucleotides/pharmacology",

author = "Wyatt, {C. N.} and P. Kumar and P. Aley and C. Peers and Hardie, {D. G.} and Evans, {A. M.}",

year = "2006",

doi = "10.1007/0-387-31311-7_29",

language = "English",

isbn = "9780387313108",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer New York",

pages = "191--196",