Does AMP-Activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Pulmonary Artery Constriction?

A. M. Evans, Kirsteen J.W. Mustard, Christopher N. Wyatt, Michelle Dipp, Nicholas P. Kinnear, D. Grahame Hardie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pulmonary arteries constricts in response to hypoxia and thereby aid ventilation-perfusion matching in the lung. Although O2-sensitive mechanisms independent of mitochondria may also play a role, it is generally accepted that relatively mild hypoxia inhibits mitochondrial oxidative phosphorylation and that this underpins, at least in part, cell activation2-6. Despite this consensus, the mechanism by which inhibition of mitochondrial oxidative phosphorylation couples to Ca2+-dependent vasoconstriction has remained elusive. To date, the field has focussed on the role of the cellular energy status (ATP), reduced redox couples and reactive oxygen species4,5 respectively, but investigation of these hypotheses has delivered conflicting data and failed to unite the field8.
Original languageEnglish
Title of host publicationThe Arterial Chemoreceptors
EditorsYoshiaki Hayashida, Constancio Gonzalez, Hisatake Kondo
PublisherSpringer New York
Pages147-154
Number of pages8
ISBN (Electronic)978-0-387-31311-5, 978-1-4899-7736-6
ISBN (Print)9780387313108
DOIs
StatePublished - 2006

Publication series

NameAdvances in Experimental Medicine and Biology
Volume580
ISSN (Print)0065-2598

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

Keywords

  • Hypoxia/*physiopathology
  • Mitochondria/*metabolism
  • Multienzyme Complexes/*metabolism
  • Protein Serine-Threonine Kinases/*metabolism
  • Pulmonary Artery/*physiopathology
  • AMP-Activated Protein Kinases
  • Calcium Signaling
  • Oxidative Phosphorylation
  • Enzyme Activation
  • In Vitro Techniques
  • Isoenzymes/metabolism
  • Male
  • Rats
  • Models, Biological
  • Muscle, Smooth,
  • Vascular/metabolism
  • Sarcoplasmic Reticulum/metabolism
  • Vasoconstriction/physiology

Disciplines

  • Neuroscience and Neurobiology
  • Molecular and Cellular Neuroscience

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