Effect of Mitochondrial Inhibitors on Type I Cells

Christopher N. Wyatt; Keith J. Buckler

doi:10.1007/978-1-4419-9280-2_7

Effect of Mitochondrial Inhibitors on Type I Cells

Christopher N. Wyatt, Keith J. Buckler

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.

Original language	English
Title of host publication	Chemorecpetion
Editors	Jean-Marc Pequignot, Yvette Dalmaz, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar
Place of Publication	Boston, MA
Publisher	Springer
Pages	55-58
Number of pages	4
ISBN (Electronic)	978-1-4419-9280-2
ISBN (Print)	978-1-4613-4873-3
DOIs	https://doi.org/10.1007/978-1-4419-9280-2_7
State	Published - 2002
Event	15th International Symposium on Arterial Chemoreception - CNRS, University Claude Bernard, Lyon, France Duration: Nov 18 2002 → Nov 22 2002

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	536
ISSN (Print)	0065-2598

Conference

Conference	15th International Symposium on Arterial Chemoreception
Country/Territory	France
City	Lyon
Period	11/18/02 → 11/22/02

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

Intracellular Calcium
Mitochondrial Function
Membrane Depolarisation
Carotid Body
Patch Clamp Technique

Disciplines

Cell Biology

Access to Document

10.1007/978-1-4419-9280-2_7

Cite this

Effect of Mitochondrial Inhibitors on Type I Cells. / Wyatt, Christopher N.; Buckler, Keith J.
Chemorecpetion. ed. / Jean-Marc Pequignot; Yvette Dalmaz; Constancio Gonzalez; Colin A. Nurse; Nanduri R. Prabhakar. Boston, MA: Springer, 2002. p. 55-58 (Advances in Experimental Medicine and Biology; Vol. 536).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wyatt, CN & Buckler, KJ 2002, Effect of Mitochondrial Inhibitors on Type I Cells. in J-M Pequignot, Y Dalmaz, C Gonzalez, CA Nurse & NR Prabhakar (eds), Chemorecpetion. Advances in Experimental Medicine and Biology, vol. 536, Springer, Boston, MA, pp. 55-58, 15th International Symposium on Arterial Chemoreception, Lyon, France, 11/18/02. https://doi.org/10.1007/978-1-4419-9280-2_7

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abstract = "Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.",

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AU - Wyatt, Christopher N.

AU - Buckler, Keith J.

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N2 - Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.

AB - Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.

KW - Intracellular Calcium

KW - Mitochondrial Function

KW - Membrane Depolarisation

KW - Carotid Body

KW - Patch Clamp Technique

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A2 - Nurse, Colin A.

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PB - Springer

CY - Boston, MA

T2 - 15th International Symposium on Arterial Chemoreception

Y2 - 18 November 2002 through 22 November 2002

ER -

Effect of Mitochondrial Inhibitors on Type I Cells

Abstract

Publication series

Conference

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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