Evidence for Amino Acid Concentration Gradients Between CSF and Extracellular Fluid

V. R. Roettger; Melvyn D. Goldfinger

doi:10.1016/0304-3940(94)90758-7

Evidence for Amino Acid Concentration Gradients Between CSF and Extracellular Fluid

V. R. Roettger, Melvyn D. Goldfinger

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

A small volume in the extracellular space of the medulla in the anesthetized cat was perfused with cisternal cerebrospinal fluid (CSF) using a push-pull technique. The recovered perfusate was a mixture of pushed CSF and the extracellular fluid. HPLC-EC analysis showed that the concentration of some primary amino acids in recovered perfusate often differed from their concentrations in CSF. These results suggested that amino acid gradients existed between CSF and the extracellular space.

Original language	American English
Journal	Neuroscience Letters
Volume	178
DOIs	https://doi.org/10.1016/0304-3940(94)90758-7
State	Published - Sep 12 1994

Keywords

Amino acids HPLC-electrochemical detection
Cerebrospinal fluid
Cuneate nucleus
Extracellular fluid
Push-pull perfusion

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

Access to Document

10.1016/0304-3940(94)90758-7License: Unspecified

Cite this

@article{94f1850e634149109b249d7343aaf6d5,

title = "Evidence for Amino Acid Concentration Gradients Between CSF and Extracellular Fluid",

abstract = " A small volume in the extracellular space of the medulla in the anesthetized cat was perfused with cisternal cerebrospinal fluid (CSF) using a push-pull technique. The recovered perfusate was a mixture of pushed CSF and the extracellular fluid. HPLC-EC analysis showed that the concentration of some primary amino acids in recovered perfusate often differed from their concentrations in CSF. These results suggested that amino acid gradients existed between CSF and the extracellular space.",

keywords = "Amino acids HPLC-electrochemical detection, Cerebrospinal fluid, Cuneate nucleus, Extracellular fluid, Push-pull perfusion",

author = "Roettger, {V. R.} and Goldfinger, {Melvyn D.}",

year = "1994",

month = sep,

day = "12",

doi = "10.1016/0304-3940(94)90758-7",

language = "American English",

volume = "178",

journal = "Neuroscience Letters",

}

TY - JOUR

T1 - Evidence for Amino Acid Concentration Gradients Between CSF and Extracellular Fluid

AU - Roettger, V. R.

AU - Goldfinger, Melvyn D.

PY - 1994/9/12

Y1 - 1994/9/12

N2 - A small volume in the extracellular space of the medulla in the anesthetized cat was perfused with cisternal cerebrospinal fluid (CSF) using a push-pull technique. The recovered perfusate was a mixture of pushed CSF and the extracellular fluid. HPLC-EC analysis showed that the concentration of some primary amino acids in recovered perfusate often differed from their concentrations in CSF. These results suggested that amino acid gradients existed between CSF and the extracellular space.

AB - A small volume in the extracellular space of the medulla in the anesthetized cat was perfused with cisternal cerebrospinal fluid (CSF) using a push-pull technique. The recovered perfusate was a mixture of pushed CSF and the extracellular fluid. HPLC-EC analysis showed that the concentration of some primary amino acids in recovered perfusate often differed from their concentrations in CSF. These results suggested that amino acid gradients existed between CSF and the extracellular space.

KW - Amino acids HPLC-electrochemical detection

KW - Cerebrospinal fluid

KW - Cuneate nucleus

KW - Extracellular fluid

KW - Push-pull perfusion

UR - https://corescholar.libraries.wright.edu/ncbp/108

U2 - 10.1016/0304-3940(94)90758-7

DO - 10.1016/0304-3940(94)90758-7

M3 - Article

VL - 178

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Evidence for Amino Acid Concentration Gradients Between CSF and Extracellular Fluid

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Cite this