Glial Modulation of CO2 Chemosensory Excitability in the Retrotrapezoid Nucleus of Rodents

Joseph S. Erlichman; Robert W. Putnam; James C. Leiter

doi:10.1007/978-0-387-73693-8_55

Glial Modulation of CO₂ Chemosensory Excitability in the Retrotrapezoid Nucleus of Rodents

Joseph S. Erlichman, Robert W. Putnam, James C. Leiter

Wright State University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We investigated the possibility that astrocytes modify the extracellular milieu and thereby modify the activity of central CO ₂ chemosensory neurons. The ability of astrocytes to modify the extracellular milieu is heterogeneously distributed among chemosensory sites that have, at least nominally, the same function. The differences in astrocytic activity may make some central chemosensory sites better attuned to the local brain tissue environment and other chemosensory sites better suited to integrate chemosensory activity from multiple sites within and outside the central nervous system.

Original language	American English
Title of host publication	Integration in Respiratory Control: From Genes to Systems
DOIs	https://doi.org/10.1007/978-0-387-73693-8_55
State	Published - Jan 1 2008

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

Access to Document

10.1007/978-0-387-73693-8_55License: Unspecified

http://dx.doi.org/10.1007/978-0-387-73693-8_55

Cite this

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title = "Glial Modulation of CO2 Chemosensory Excitability in the Retrotrapezoid Nucleus of Rodents",

abstract = " We investigated the possibility that astrocytes modify the extracellular milieu and thereby modify the activity of central CO 2 chemosensory neurons. The ability of astrocytes to modify the extracellular milieu is heterogeneously distributed among chemosensory sites that have, at least nominally, the same function. The differences in astrocytic activity may make some central chemosensory sites better attuned to the local brain tissue environment and other chemosensory sites better suited to integrate chemosensory activity from multiple sites within and outside the central nervous system.",

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