HLA DQA1∗05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children with Crohn's Disease

Jeremy Adler; Joseph A. Galanko; Rana Ammoury; Keith J. Benkov; Athos Bousvaros; Brendan Boyle; José M. Cabrera; Kelly Y. Chun; Jill Dorsey; Dawn R. Ebach; Ann M. Firestine; Ajay S. Gulati; Hans H. Herfarth; Traci W. Jester; Jess L. Kaplan; Ian Leibowitz; Tiffany M. Linville; Peter A. Margolis; Phillip Minar; Zarela Molle-Rios; Jonathan Moses; Kelly Olano; Dinesh S. Pashankar; Lisa Pitch; Shehzad A. Saeed; Charles M. Samson; Kelly Sandberg; Steven J. Steiner; Jennifer A. Strople; Jillian S. Sullivan; Prateek D. Wali; Michael D. Kappelman

doi:10.14309/ajg.0000000000003135

HLA DQA1∗05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children with Crohn's Disease

Jeremy Adler, Joseph A. Galanko, Rana Ammoury, Keith J. Benkov, Athos Bousvaros, Brendan Boyle, José M. Cabrera, Kelly Y. Chun, Jill Dorsey, Dawn R. Ebach, Ann M. Firestine, Ajay S. Gulati, Hans H. Herfarth, Traci W. Jester, Jess L. Kaplan, Ian Leibowitz, Tiffany M. Linville, Peter A. Margolis, Phillip Minar, Zarela Molle-RiosJonathan Moses, Kelly Olano, Dinesh S. Pashankar, Lisa Pitch, Shehzad A. Saeed, Charles M. Samson, Kelly Sandberg, Steven J. Steiner, Jennifer A. Strople, Jillian S. Sullivan, Prateek D. Wali, Michael D. Kappelman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1076-1086
Number of pages	11
Journal	American Journal of Gastroenterology
Volume	120
Issue number	5
DOIs	https://doi.org/10.14309/ajg.0000000000003135
State	Published - May 1 2025
Externally published	Yes

ASJC Scopus Subject Areas

Hepatology
Gastroenterology

Keywords

drug persistence
genotype
loss of response
pediatric

Access to Document

10.14309/ajg.0000000000003135

Cite this

Adler, J., Galanko, J. A., Ammoury, R., Benkov, K. J., Bousvaros, A., Boyle, B., Cabrera, J. M., Chun, K. Y., Dorsey, J., Ebach, D. R., Firestine, A. M., Gulati, A. S., Herfarth, H. H., Jester, T. W., Kaplan, J. L., Leibowitz, I., Linville, T. M., Margolis, P. A., Minar, P., ... Kappelman, M. D. (2025). HLA DQA1∗05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children with Crohn's Disease. American Journal of Gastroenterology, 120(5), 1076-1086. https://doi.org/10.14309/ajg.0000000000003135

Adler, J, Galanko, JA, Ammoury, R, Benkov, KJ, Bousvaros, A, Boyle, B, Cabrera, JM, Chun, KY, Dorsey, J, Ebach, DR, Firestine, AM, Gulati, AS, Herfarth, HH, Jester, TW, Kaplan, JL, Leibowitz, I, Linville, TM, Margolis, PA, Minar, P, Molle-Rios, Z, Moses, J, Olano, K, Pashankar, DS, Pitch, L, Saeed, SA, Samson, CM, Sandberg, K, Steiner, SJ, Strople, JA, Sullivan, JS, Wali, PD & Kappelman, MD 2025, 'HLA DQA1∗05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children with Crohn's Disease', American Journal of Gastroenterology, vol. 120, no. 5, pp. 1076-1086. https://doi.org/10.14309/ajg.0000000000003135

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title = "HLA DQA1∗05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children with Crohn's Disease",

keywords = "drug persistence, genotype, loss of response, pediatric",

author = "Jeremy Adler and Galanko, \{Joseph A.\} and Rana Ammoury and Benkov, \{Keith J.\} and Athos Bousvaros and Brendan Boyle and Cabrera, \{Jos{\'e} M.\} and Chun, \{Kelly Y.\} and Jill Dorsey and Ebach, \{Dawn R.\} and Firestine, \{Ann M.\} and Gulati, \{Ajay S.\} and Herfarth, \{Hans H.\} and Jester, \{Traci W.\} and Kaplan, \{Jess L.\} and Ian Leibowitz and Linville, \{Tiffany M.\} and Margolis, \{Peter A.\} and Phillip Minar and Zarela Molle-Rios and Jonathan Moses and Kelly Olano and Pashankar, \{Dinesh S.\} and Lisa Pitch and Saeed, \{Shehzad A.\} and Samson, \{Charles M.\} and Kelly Sandberg and Steiner, \{Steven J.\} and Strople, \{Jennifer A.\} and Sullivan, \{Jillian S.\} and Wali, \{Prateek D.\} and Kappelman, \{Michael D.\}",

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doi = "10.14309/ajg.0000000000003135",

language = "English",

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AU - Adler, Jeremy

AU - Galanko, Joseph A.

AU - Ammoury, Rana

AU - Benkov, Keith J.

AU - Bousvaros, Athos

AU - Boyle, Brendan

AU - Cabrera, José M.

AU - Chun, Kelly Y.

AU - Dorsey, Jill

AU - Ebach, Dawn R.

AU - Firestine, Ann M.

AU - Gulati, Ajay S.

AU - Herfarth, Hans H.

AU - Jester, Traci W.

AU - Kaplan, Jess L.

AU - Leibowitz, Ian

AU - Linville, Tiffany M.

AU - Margolis, Peter A.

AU - Minar, Phillip

AU - Molle-Rios, Zarela

AU - Moses, Jonathan

AU - Olano, Kelly

AU - Pashankar, Dinesh S.

AU - Pitch, Lisa

AU - Saeed, Shehzad A.

AU - Samson, Charles M.

AU - Sandberg, Kelly

AU - Steiner, Steven J.

AU - Strople, Jennifer A.

AU - Sullivan, Jillian S.

AU - Wali, Prateek D.

AU - Kappelman, Michael D.

PY - 2025/5/1

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KW - genotype

KW - loss of response

KW - pediatric

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HLA DQA1∗05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children with Crohn's Disease

ASJC Scopus Subject Areas

Keywords

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