@inproceedings{797d6c2d307341c085e3230719fafbab,
title = "Key Roles for AMP-Activated Protein Kinase in the Function of the Carotid Body?",
abstract = "The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.",
keywords = "Carotid Boyd, DU145 Cell, Intermittent Hypoxia, Mitochondrial Oxidative Phosphorylation, Chronic Intermittent Hypoxia",
author = "Wyatt, {Christopher N.} and Pearson, {Selina A.} and Prem Kumar and Chris Peers and Hardie, {D. Grahame} and Evans, {A. Mark}",
year = "2008",
doi = "10.1007/978-0-387-73693-8_11",
language = "English",
isbn = "978-0-387-73692-1",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "63--68",
editor = "Marc Poulin and Richard Wilson",
booktitle = "Integration in Respiratory Control",
note = "X Oxford Conference ; Conference date: 19-09-2006 Through 24-09-2006",
}