Key roles for AMP-activated protein kinase in the function of the carotid body?

Christopher N. Wyatt; Selina A. Pearson; Prem Kumar; Chris Peers; D. Grahame Hardie; A. Mark Evans

doi:10.1007/978-0-387-73693-8_11

Key roles for AMP-activated protein kinase in the function of the carotid body?

Christopher N. Wyatt, Selina A. Pearson, Prem Kumar, Chris Peers, D. Grahame Hardie, A. Mark Evans

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.

Original language	English
Title of host publication	Integration in Respiratory Control
Subtitle of host publication	From Genes to Systems
Editors	Marc Poulin, Richard Wilson
Publisher	Springer New York LLC
Pages	63-68
Number of pages	6
ISBN (Electronic)	978-0-387-73693-8
ISBN (Print)	978-0-387-73692-1, 978-1-4419-2529-9
DOIs	https://doi.org/10.1007/978-0-387-73693-8_11
State	Published - 2008

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	605
ISSN (Print)	0065-2598

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

Carotid Boyd
DU145 Cell
Intermittent Hypoxia
Mitochondrial Oxidative Phosphorylation
Chronic Intermittent Hypoxia

Access to Document

10.1007/978-0-387-73693-8_11

Cite this

Wyatt, C. N., Pearson, S. A., Kumar, P., Peers, C., Hardie, D. G., & Evans, A. M. (2008). Key roles for AMP-activated protein kinase in the function of the carotid body? In M. Poulin, & R. Wilson (Eds.), Integration in Respiratory Control: From Genes to Systems (pp. 63-68). (Advances in Experimental Medicine and Biology; Vol. 605). Springer New York LLC. https://doi.org/10.1007/978-0-387-73693-8_11

Key roles for AMP-activated protein kinase in the function of the carotid body? / Wyatt, Christopher N.; Pearson, Selina A.; Kumar, Prem et al.
Integration in Respiratory Control: From Genes to Systems. ed. / Marc Poulin; Richard Wilson. Springer New York LLC, 2008. p. 63-68 (Advances in Experimental Medicine and Biology; Vol. 605).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wyatt, CN, Pearson, SA, Kumar, P, Peers, C, Hardie, DG & Evans, AM 2008, Key roles for AMP-activated protein kinase in the function of the carotid body? in M Poulin & R Wilson (eds), Integration in Respiratory Control: From Genes to Systems. Advances in Experimental Medicine and Biology, vol. 605, Springer New York LLC, pp. 63-68. https://doi.org/10.1007/978-0-387-73693-8_11

@inproceedings{797d6c2d307341c085e3230719fafbab,

title = "Key roles for AMP-activated protein kinase in the function of the carotid body?",

abstract = "The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.",

keywords = "Carotid Boyd, DU145 Cell, Intermittent Hypoxia, Mitochondrial Oxidative Phosphorylation, Chronic Intermittent Hypoxia",

author = "Wyatt, {Christopher N.} and Pearson, {Selina A.} and Prem Kumar and Chris Peers and Hardie, {D. Grahame} and Evans, {A. Mark}",

year = "2008",

doi = "10.1007/978-0-387-73693-8_11",

language = "English",

isbn = "978-0-387-73692-1",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer New York LLC",

pages = "63--68",