MicroRNA Involvement in the Onset and Progression of Barrett’s Esophagus: A Systematic Review

Reilly J. Clark; Michael P. Craig; Sangeeta Agrawal; Madhavi Kadakia

doi:10.18632/oncotarget.24145

MicroRNA Involvement in the Onset and Progression of Barrett’s Esophagus: A Systematic Review

Reilly J. Clark, Michael P. Craig, Sangeeta Agrawal, Madhavi Kadakia

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that develops from Barrett's esophagus (BE), an intestinal metaplasia of the distal esophagus. microRNAs (miRNAs), short non-coding regulatory RNAs, are frequently dysregulated in BE and are thought to play key roles in the onset of BE and its progression to EAC. miRNAs thus have potential diagnostic and prognostic value and are increasingly being used as cancer biomarkers. This review summarizes the current literature related to miRNAs that are dysregulated in BE within the context of Hedgehog, Notch, MAPK, NF kappa-B, Wnt and epithelial-mesenchymal transition (EMT) signaling which are thought to drive BE onset and progression. This comprehensive analysis of miRNAs and their associated signaling in the regulation of BE provides an overview of vital discoveries in this field and highlights gaps in our understanding of BE pathophysiology that warrant further investigation.

Original language	American English
Journal	Oncotarget
Volume	9
DOIs	https://doi.org/10.18632/oncotarget.24145
State	Published - Jan 30 2018

Keywords

Barrett’s esophagus
EAC
biomarker
microRNA

Disciplines

Biochemistry, Biophysics, and Structural Biology
Life Sciences
Molecular Biology

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title = "MicroRNA Involvement in the Onset and Progression of Barrett{\textquoteright}s Esophagus: A Systematic Review",

abstract = " Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that develops from Barrett's esophagus (BE), an intestinal metaplasia of the distal esophagus. microRNAs (miRNAs), short non-coding regulatory RNAs, are frequently dysregulated in BE and are thought to play key roles in the onset of BE and its progression to EAC. miRNAs thus have potential diagnostic and prognostic value and are increasingly being used as cancer biomarkers. This review summarizes the current literature related to miRNAs that are dysregulated in BE within the context of Hedgehog, Notch, MAPK, NF kappa-B, Wnt and epithelial-mesenchymal transition (EMT) signaling which are thought to drive BE onset and progression. This comprehensive analysis of miRNAs and their associated signaling in the regulation of BE provides an overview of vital discoveries in this field and highlights gaps in our understanding of BE pathophysiology that warrant further investigation.",

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AU - Clark, Reilly J.

AU - Craig, Michael P.

AU - Agrawal, Sangeeta

AU - Kadakia, Madhavi

PY - 2018/1/30

Y1 - 2018/1/30

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AB - Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that develops from Barrett's esophagus (BE), an intestinal metaplasia of the distal esophagus. microRNAs (miRNAs), short non-coding regulatory RNAs, are frequently dysregulated in BE and are thought to play key roles in the onset of BE and its progression to EAC. miRNAs thus have potential diagnostic and prognostic value and are increasingly being used as cancer biomarkers. This review summarizes the current literature related to miRNAs that are dysregulated in BE within the context of Hedgehog, Notch, MAPK, NF kappa-B, Wnt and epithelial-mesenchymal transition (EMT) signaling which are thought to drive BE onset and progression. This comprehensive analysis of miRNAs and their associated signaling in the regulation of BE provides an overview of vital discoveries in this field and highlights gaps in our understanding of BE pathophysiology that warrant further investigation.

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KW - biomarker

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MicroRNA Involvement in the Onset and Progression of Barrett’s Esophagus: A Systematic Review

Abstract

Keywords

Disciplines

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