Next‐Generation Heteronuclear Decoupling for High‐Field Biomolecular NMR Spectroscopy

Franz Schilling; Lisa R. Warner; Naum I. Gershenzon; Thomas E. Skinner; Michael Sattler; Steffen J. Glaser

doi:10.1002/anie.201400178

Next‐Generation Heteronuclear Decoupling for High‐Field Biomolecular NMR Spectroscopy

Franz Schilling, Lisa R. Warner, Naum I. Gershenzon, Thomas E. Skinner, Michael Sattler, Steffen J. Glaser

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

<p> Ultra&hyphen;high&hyphen;field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low&hyphen;power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra&hyphen;low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state&hyphen;of&hyphen;the&hyphen;art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high&hyphen;field biomolecular NMR spectroscopy.</p>

Original language	American English
Journal	Angewandte Chemie International Edition
Volume	53
DOIs	https://doi.org/10.1002/anie.201400178
State	Published - Apr 22 2014

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Physical Sciences and Mathematics
Physics

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10.1002/anie.201400178License: CC BY

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title = "Next‐Generation Heteronuclear Decoupling for High‐Field Biomolecular NMR Spectroscopy",

abstract = " Ultra&hyphen;high&hyphen;field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low&hyphen;power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra&hyphen;low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state&hyphen;of&hyphen;the&hyphen;art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high&hyphen;field biomolecular NMR spectroscopy.",

author = "Franz Schilling and Warner, {Lisa R.} and Gershenzon, {Naum I.} and Skinner, {Thomas E.} and Michael Sattler and Glaser, {Steffen J.}",

year = "2014",

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doi = "10.1002/anie.201400178",

language = "American English",

volume = "53",

journal = "Angewandte Chemie International Edition",

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AU - Schilling, Franz

AU - Warner, Lisa R.

AU - Gershenzon, Naum I.

AU - Skinner, Thomas E.

AU - Sattler, Michael

AU - Glaser, Steffen J.

PY - 2014/4/22

Y1 - 2014/4/22

N2 - Ultra&hyphen;high&hyphen;field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low&hyphen;power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra&hyphen;low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state&hyphen;of&hyphen;the&hyphen;art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high&hyphen;field biomolecular NMR spectroscopy.

AB - Ultra&hyphen;high&hyphen;field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low&hyphen;power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra&hyphen;low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state&hyphen;of&hyphen;the&hyphen;art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high&hyphen;field biomolecular NMR spectroscopy.

UR - https://corescholar.libraries.wright.edu/physics/1039

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DO - 10.1002/anie.201400178

M3 - Article

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VL - 53

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

ER -

Next‐Generation Heteronuclear Decoupling for High‐Field Biomolecular NMR Spectroscopy

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