No Effect of Smoking on Sulfamethazine Acetylation

Marvin E. Miller; Janice M. Cosgriff

No Effect of Smoking on Sulfamethazine Acetylation

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

Seven healthy subjects who smoked at least one pack of cigarettes/d were acetylator-phenotyped with sulfamethazine (SMZ) while they were actively smoking, and again at least one month after they had completely stopped. There were no significant differences of the acetylation profiles in the smoking vs. nonsmoking state, as measured by %ASMZ in serum six hours post-SMZ dosing or by %ASMZ in urine five to six hours post-SMZ dosing. We conclude that smoking does not influence SMZ acetylation and probably does not affect drug acetylation in general.

Original language	American English
Journal	Drug Intelligence & Clinical Pharmacy
Volume	18
State	Published - Jan 1 1984

Keywords

Acetylation
Smoking
Sulfamethazine

Disciplines

Medical Specialties
Medicine and Health Sciences
Pediatrics

Cite this

@article{409526b4e611403abc3eb86a7c4dcd1f,

title = "No Effect of Smoking on Sulfamethazine Acetylation",

abstract = " Seven healthy subjects who smoked at least one pack of cigarettes/d were acetylator-phenotyped with sulfamethazine (SMZ) while they were actively smoking, and again at least one month after they had completely stopped. There were no significant differences of the acetylation profiles in the smoking vs. nonsmoking state, as measured by %ASMZ in serum six hours post-SMZ dosing or by %ASMZ in urine five to six hours post-SMZ dosing. We conclude that smoking does not influence SMZ acetylation and probably does not affect drug acetylation in general.",

keywords = "Acetylation, Smoking, Sulfamethazine",

author = "Miller, {Marvin E.} and Cosgriff, {Janice M.}",

year = "1984",

month = jan,

day = "1",

language = "American English",

volume = "18",

journal = "Drug Intelligence & Clinical Pharmacy",

}

TY - JOUR

T1 - No Effect of Smoking on Sulfamethazine Acetylation

AU - Miller, Marvin E.

AU - Cosgriff, Janice M.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Seven healthy subjects who smoked at least one pack of cigarettes/d were acetylator-phenotyped with sulfamethazine (SMZ) while they were actively smoking, and again at least one month after they had completely stopped. There were no significant differences of the acetylation profiles in the smoking vs. nonsmoking state, as measured by %ASMZ in serum six hours post-SMZ dosing or by %ASMZ in urine five to six hours post-SMZ dosing. We conclude that smoking does not influence SMZ acetylation and probably does not affect drug acetylation in general.

AB - Seven healthy subjects who smoked at least one pack of cigarettes/d were acetylator-phenotyped with sulfamethazine (SMZ) while they were actively smoking, and again at least one month after they had completely stopped. There were no significant differences of the acetylation profiles in the smoking vs. nonsmoking state, as measured by %ASMZ in serum six hours post-SMZ dosing or by %ASMZ in urine five to six hours post-SMZ dosing. We conclude that smoking does not influence SMZ acetylation and probably does not affect drug acetylation in general.

KW - Acetylation

KW - Smoking

KW - Sulfamethazine

UR - https://corescholar.libraries.wright.edu/pediatrics/30

M3 - Article

VL - 18

JO - Drug Intelligence & Clinical Pharmacy

JF - Drug Intelligence & Clinical Pharmacy

ER -

No Effect of Smoking on Sulfamethazine Acetylation

Abstract

Keywords

Disciplines

Other files and links

Cite this