Optimal single-arm two-stage designs with consideration of dependency on efficacy and safety

Huan Yin; Weizhen Wang; Zhongzhan Zhang

doi:10.1177/09622802221111553

Optimal single-arm two-stage designs with consideration of dependency on efficacy and safety

Huan Yin, Weizhen Wang, Zhongzhan Zhang

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2021-2034
Number of pages	14
Journal	Statistical Methods in Medical Research
Volume	31
Issue number	10
DOIs	https://doi.org/10.1177/09622802221111553
State	Published - Oct 2022

ASJC Scopus Subject Areas

Epidemiology
Statistics and Probability
Health Information Management

Keywords

Dimensionality reduction
exact test
expected sample size
multinomial distribution
phase II clinical trial

Disciplines

Applied Mathematics
Applied Statistics
Mathematics
Physical Sciences and Mathematics
Statistics and Probability

Access to Document

10.1177/09622802221111553

Cite this

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title = "Optimal single-arm two-stage designs with consideration of dependency on efficacy and safety",

keywords = "Dimensionality reduction, exact test, expected sample size, multinomial distribution, phase II clinical trial",

author = "Huan Yin and Weizhen Wang and Zhongzhan Zhang",

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year = "2022",

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doi = "10.1177/09622802221111553",

language = "English",

volume = "31",

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journal = "Statistical Methods in Medical Research",

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T1 - Optimal single-arm two-stage designs with consideration of dependency on efficacy and safety

AU - Yin, Huan

AU - Wang, Weizhen

AU - Zhang, Zhongzhan

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/10

Y1 - 2022/10

KW - Dimensionality reduction

KW - exact test

KW - expected sample size

KW - multinomial distribution

KW - phase II clinical trial

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M3 - Article

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SN - 0962-2802

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JO - Statistical Methods in Medical Research

JF - Statistical Methods in Medical Research

IS - 10

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Optimal single-arm two-stage designs with consideration of dependency on efficacy and safety

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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Cite this