Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates

Wojciech Krzyzanski; Sarah F. Cook; Melanie Wilbaux; Catherine M.T. Sherwin; Karel Allegaert; An Vermeulen; John N. van den Anker

doi:10.1208/s12248-019-0331-0

Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates

Wojciech Krzyzanski, Sarah F. Cook, Melanie Wilbaux, Catherine M.T. Sherwin, Karel Allegaert, An Vermeulen, John N. van den Anker

Wright State University

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	68
Journal	AAPS Journal
Volume	21
Issue number	4
DOIs	https://doi.org/10.1208/s12248-019-0331-0
State	Published - Jul 1 2019

ASJC Scopus Subject Areas

Pharmaceutical Science

Keywords

full random effects model
missing covariates
paracetamol
pediatric population

Disciplines

Medical Specialties
Medicine and Health Sciences
Pediatrics

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10.1208/s12248-019-0331-0

Cite this

@article{c37e5ea651fc44de84fb1fb492ac51b3,

title = "Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates",

keywords = "full random effects model, missing covariates, paracetamol, pediatric population",

author = "Wojciech Krzyzanski and Cook, {Sarah F.} and Melanie Wilbaux and Sherwin, {Catherine M.T.} and Karel Allegaert and An Vermeulen and {van den Anker}, {John N.}",

note = "Publisher Copyright: {\textcopyright} 2019, American Association of Pharmaceutical Scientists.",

year = "2019",

month = jul,

day = "1",

doi = "10.1208/s12248-019-0331-0",

language = "English",

volume = "21",

journal = "AAPS Journal",

issn = "1550-7416",

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T1 - Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates

T2 - Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates

AU - Krzyzanski, Wojciech

AU - Cook, Sarah F.

AU - Wilbaux, Melanie

AU - Sherwin, Catherine M.T.

AU - Allegaert, Karel

AU - Vermeulen, An

AU - van den Anker, John N.

PY - 2019/7/1

Y1 - 2019/7/1

KW - full random effects model

KW - missing covariates

KW - paracetamol

KW - pediatric population

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UR - https://corescholar.libraries.wright.edu/pediatrics/302

U2 - 10.1208/s12248-019-0331-0

DO - 10.1208/s12248-019-0331-0

M3 - Article

C2 - 31140019

AN - SCOPUS:85066496875

SN - 1550-7416

VL - 21

JO - AAPS Journal

JF - AAPS Journal

IS - 4

M1 - 68

ER -

Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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