Recovery by Push-Pull Perfusion of Neurochemicals Released Within the Cuneate Nucleus of the Cat by Somatosensory Stimulation

Melvyn D. Goldfinger; C. Wayne Simpson; Garth E. Resch

doi:10.1016/0091-3057(84)90140-0

Recovery by Push-Pull Perfusion of Neurochemicals Released Within the Cuneate Nucleus of the Cat by Somatosensory Stimulation

Melvyn D. Goldfinger, C. Wayne Simpson, Garth E. Resch

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

The present work describes a combination of techniques for the identification of neurochemicals released within the cuneate nucleus. During electrical stimulation of the superficial radial nerve, the extracellular fluid of the nucleus is continuously sampled by push-pull perfusion. In addition, the population electrical activity of peripheral nerve as well as the activity of cuneate neurons are recorded. Subsequently, the neurochemical content of the sampled fluid is assessed by HPLC analysis. The comparison of sampled fluid content during control (no stimulation) versus stimulation runs indicates that somatosensory stimulation elicits the release of specific neurochemicals within the cuneate nucleus. The possible sources of released neurochemicals are discussed.

Original language	American English
Journal	Pharmacology Biochemistry and Behavior
Volume	21
DOIs	https://doi.org/10.1016/0091-3057(84)90140-0
State	Published - Jul 1 1984

Keywords

Catecholamine and indoleamine metabolites
Cuneate nucleus
Electrical stimulation
HPLC
Push-pull perfusion
Superficial radial nerve

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

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title = "Recovery by Push-Pull Perfusion of Neurochemicals Released Within the Cuneate Nucleus of the Cat by Somatosensory Stimulation",

abstract = "The present work describes a combination of techniques for the identification of neurochemicals released within the cuneate nucleus. During electrical stimulation of the superficial radial nerve, the extracellular fluid of the nucleus is continuously sampled by push-pull perfusion. In addition, the population electrical activity of peripheral nerve as well as the activity of cuneate neurons are recorded. Subsequently, the neurochemical content of the sampled fluid is assessed by HPLC analysis. The comparison of sampled fluid content during control (no stimulation) versus stimulation runs indicates that somatosensory stimulation elicits the release of specific neurochemicals within the cuneate nucleus. The possible sources of released neurochemicals are discussed.",

keywords = "Catecholamine and indoleamine metabolites, Cuneate nucleus, Electrical stimulation, HPLC, Push-pull perfusion, Superficial radial nerve",

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AU - Goldfinger, Melvyn D.

AU - Simpson, C. Wayne

AU - Resch, Garth E.

PY - 1984/7/1

Y1 - 1984/7/1

N2 - The present work describes a combination of techniques for the identification of neurochemicals released within the cuneate nucleus. During electrical stimulation of the superficial radial nerve, the extracellular fluid of the nucleus is continuously sampled by push-pull perfusion. In addition, the population electrical activity of peripheral nerve as well as the activity of cuneate neurons are recorded. Subsequently, the neurochemical content of the sampled fluid is assessed by HPLC analysis. The comparison of sampled fluid content during control (no stimulation) versus stimulation runs indicates that somatosensory stimulation elicits the release of specific neurochemicals within the cuneate nucleus. The possible sources of released neurochemicals are discussed.

AB - The present work describes a combination of techniques for the identification of neurochemicals released within the cuneate nucleus. During electrical stimulation of the superficial radial nerve, the extracellular fluid of the nucleus is continuously sampled by push-pull perfusion. In addition, the population electrical activity of peripheral nerve as well as the activity of cuneate neurons are recorded. Subsequently, the neurochemical content of the sampled fluid is assessed by HPLC analysis. The comparison of sampled fluid content during control (no stimulation) versus stimulation runs indicates that somatosensory stimulation elicits the release of specific neurochemicals within the cuneate nucleus. The possible sources of released neurochemicals are discussed.

KW - Catecholamine and indoleamine metabolites

KW - Cuneate nucleus

KW - Electrical stimulation

KW - HPLC

KW - Push-pull perfusion

KW - Superficial radial nerve

UR - https://corescholar.libraries.wright.edu/ncbp/691

U2 - 10.1016/0091-3057(84)90140-0

DO - 10.1016/0091-3057(84)90140-0

M3 - Article

VL - 21

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

ER -

Recovery by Push-Pull Perfusion of Neurochemicals Released Within the Cuneate Nucleus of the Cat by Somatosensory Stimulation

Abstract

Keywords

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