Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue

Hunter A. Martinez; Ievgen Koliesnik; Gernot Kaber; Jacqueline K. Reid; Nadine Nagy; Graham Barlow; Ben A. Falk; Carlos O. Medina; Aviv Hargil; Svenja Zihsler; Israel Vlodavsky; Jin Ping Li; Magdiel Pérez-Cruz; Sai Wen Tang; Everett H. Meyer; Lucile E. Wrenshall; James D. Lord; K. Christopher Garcia; Theo D. Palmer; Lawrence Steinman; Gerald T. Nepom; Thomas N. Wight; Paul L. Bollyky; Hedwich F. Kuipers

doi:10.1038/s41467-024-45012-9

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue

Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin Ping Li, Magdiel Pérez-Cruz, Sai Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence SteinmanGerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	1564
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-45012-9
State	Published - Dec 2024
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General
General Physics and Astronomy

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10.1038/s41467-024-45012-9

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Martinez, H. A., Koliesnik, I., Kaber, G., Reid, J. K., Nagy, N., Barlow, G., Falk, B. A., Medina, C. O., Hargil, A., Zihsler, S., Vlodavsky, I., Li, J. P., Pérez-Cruz, M., Tang, S. W., Meyer, E. H., Wrenshall, L. E., Lord, J. D., Garcia, K. C., Palmer, T. D., ... Kuipers, H. F. (2024). Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature Communications, 15(1), Article 1564. https://doi.org/10.1038/s41467-024-45012-9

Martinez, HA, Koliesnik, I, Kaber, G, Reid, JK, Nagy, N, Barlow, G, Falk, BA, Medina, CO, Hargil, A, Zihsler, S, Vlodavsky, I, Li, JP, Pérez-Cruz, M, Tang, SW, Meyer, EH, Wrenshall, LE, Lord, JD, Garcia, KC, Palmer, TD, Steinman, L, Nepom, GT, Wight, TN, Bollyky, PL & Kuipers, HF 2024, 'Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue', Nature Communications, vol. 15, no. 1, 1564. https://doi.org/10.1038/s41467-024-45012-9

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title = "Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue",

author = "Martinez, \{Hunter A.\} and Ievgen Koliesnik and Gernot Kaber and Reid, \{Jacqueline K.\} and Nadine Nagy and Graham Barlow and Falk, \{Ben A.\} and Medina, \{Carlos O.\} and Aviv Hargil and Svenja Zihsler and Israel Vlodavsky and Li, \{Jin Ping\} and Magdiel P{\'e}rez-Cruz and Tang, \{Sai Wen\} and Meyer, \{Everett H.\} and Wrenshall, \{Lucile E.\} and Lord, \{James D.\} and Garcia, \{K. Christopher\} and Palmer, \{Theo D.\} and Lawrence Steinman and Nepom, \{Gerald T.\} and Wight, \{Thomas N.\} and Bollyky, \{Paul L.\} and Kuipers, \{Hedwich F.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

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doi = "10.1038/s41467-024-45012-9",

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T1 - Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue

AU - Martinez, Hunter A.

AU - Koliesnik, Ievgen

AU - Kaber, Gernot

AU - Reid, Jacqueline K.

AU - Nagy, Nadine

AU - Barlow, Graham

AU - Falk, Ben A.

AU - Medina, Carlos O.

AU - Hargil, Aviv

AU - Zihsler, Svenja

AU - Vlodavsky, Israel

AU - Li, Jin Ping

AU - Pérez-Cruz, Magdiel

AU - Tang, Sai Wen

AU - Meyer, Everett H.

AU - Wrenshall, Lucile E.

AU - Lord, James D.

AU - Garcia, K. Christopher

AU - Palmer, Theo D.

AU - Steinman, Lawrence

AU - Nepom, Gerald T.

AU - Wight, Thomas N.

AU - Bollyky, Paul L.

AU - Kuipers, Hedwich F.

PY - 2024/12

Y1 - 2024/12

UR - https://www.scopus.com/pages/publications/85185497635

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DO - 10.1038/s41467-024-45012-9

M3 - Article

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AN - SCOPUS:85185497635

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1564

ER -

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue

ASJC Scopus Subject Areas

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