TY - JOUR
T1 - Relation of age to effects of phentolamine and phenylephrine on heart
AU - Xu, H.
AU - Gelband, H.
AU - McCormack, J.
AU - Pickoff, A. S.
AU - Stolfi, A.
PY - 1993/3/1
Y1 - 1993/3/1
N2 - In the present study, the responses of neonatal and adult dog hearts to phenylephrine (PE) and phentolaminie (PA) were investigated in order to determine the influence of age factors. PA resulted in the slowing of the heart rate, the prolongation of corrected sinus node recover time, atrial refractory period (ARP), ventricular effective refractory period (VERP), and ventricular functional refractory period (VFRP), and a significant inhibition of conducting tissues in neonatal dogs. PE had a positive chronotropic effect in neonatal dogs but no such effect in adult dogs. In conclusion, a-adrenoceptors played an important excitatory role in the neonatal dog heart.
AB - In the present study, the responses of neonatal and adult dog hearts to phenylephrine (PE) and phentolaminie (PA) were investigated in order to determine the influence of age factors. PA resulted in the slowing of the heart rate, the prolongation of corrected sinus node recover time, atrial refractory period (ARP), ventricular effective refractory period (VERP), and ventricular functional refractory period (VFRP), and a significant inhibition of conducting tissues in neonatal dogs. PE had a positive chronotropic effect in neonatal dogs but no such effect in adult dogs. In conclusion, a-adrenoceptors played an important excitatory role in the neonatal dog heart.
UR - http://www.scopus.com/inward/record.url?scp=0027511568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027511568&partnerID=8YFLogxK
UR - https://corescholar.libraries.wright.edu/med_education/150
UR - https://pubmed.ncbi.nlm.nih.gov/8351998/
M3 - Article
C2 - 8351998
AN - SCOPUS:0027511568
SN - 0253-9756
VL - 14
SP - 106
EP - 109
JO - Acta Pharmacologica Sinica
JF - Acta Pharmacologica Sinica
IS - 2
ER -