Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice

Cheryl L. Gould; Mary L. Trombley; Nancy J. Bigley; Karyle G. McMannama; David J. Giron

doi:10.3181/00379727-175-41819

Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice

Cheryl L. Gould, Mary L. Trombley, Nancy J. Bigley, Karyle G. McMannama, David J. Giron

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Contribution to journal › Article › peer-review

Abstract

The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.

Original language	English
Pages (from-to)	449-453
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	175
Issue number	4
DOIs	https://doi.org/10.3181/00379727-175-41819
State	Published - Apr 1984

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

diabetogenci D
nondiabetogenic B
EMC-D
EMC-B
encephalomyocarditis virus
mice

Disciplines

Medicine and Health Sciences
Molecular Biology

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10.3181/00379727-175-41819

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title = "Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice",

abstract = "The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.",

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AU - Gould, Cheryl L.

AU - Trombley, Mary L.

AU - Bigley, Nancy J.

AU - McMannama, Karyle G.

AU - Giron, David J.

PY - 1984/4

Y1 - 1984/4

N2 - The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.

AB - The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.

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KW - nondiabetogenic B

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Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice

Abstract

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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