Abstract
The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.
| Original language | English |
|---|---|
| Pages (from-to) | 449-453 |
| Number of pages | 5 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 175 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1984 |
ASJC Scopus Subject Areas
- General Biochemistry,Genetics and Molecular Biology
Keywords
- diabetogenci D
- nondiabetogenic B
- EMC-D
- EMC-B
- encephalomyocarditis virus
- mice
Disciplines
- Medicine and Health Sciences
- Molecular Biology