Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α

Courtney B. Johnson-Gonzalez; Scout Bowman-Gibson; Chandni H. Chandiramani; Bryce A. Linkous; Kailey C. Nolan; Emily K. Stone; Katherine E. Wilcher; Mili S. Bhakta-Yadav; Rose A. Maxwell; David N. Dhanraj; Thomas L. Brown

doi:10.1016/j.placenta.2026.03.020

Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α

Courtney B. Johnson-Gonzalez
, Scout Bowman-Gibson
, Chandni H. Chandiramani
, Bryce A. Linkous
, Kailey C. Nolan
, Emily K. Stone
, Katherine E. Wilcher
, Mili S. Bhakta-Yadav
, Rose A. Maxwell
, David N. Dhanraj
, Thomas L. Brown

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	40-52
Number of pages	13
Journal	Placenta
Volume	179
DOIs	https://doi.org/10.1016/j.placenta.2026.03.020
State	Published - May 22 2026
Externally published	Yes

ASJC Scopus Subject Areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

Keywords

Cellular energy
HIF-1 alpha
Metabolism
Placenta
Preeclampsia

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10.1016/j.placenta.2026.03.020

Cite this

Johnson-Gonzalez, C. B., Bowman-Gibson, S., Chandiramani, C. H., Linkous, B. A., Nolan, K. C., Stone, E. K., Wilcher, K. E., Bhakta-Yadav, M. S., Maxwell, R. A., Dhanraj, D. N., & Brown, T. L. (2026). Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α. Placenta, 179, 40-52. https://doi.org/10.1016/j.placenta.2026.03.020

Johnson-Gonzalez, CB, Bowman-Gibson, S, Chandiramani, CH, Linkous, BA, Nolan, KC, Stone, EK, Wilcher, KE, Bhakta-Yadav, MS, Maxwell, RA, Dhanraj, DN & Brown, TL 2026, 'Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α', Placenta, vol. 179, pp. 40-52. https://doi.org/10.1016/j.placenta.2026.03.020

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title = "Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α",

keywords = "Cellular energy, HIF-1 alpha, Metabolism, Placenta, Preeclampsia",

author = "Johnson-Gonzalez, \{Courtney B.\} and Scout Bowman-Gibson and Chandiramani, \{Chandni H.\} and Linkous, \{Bryce A.\} and Nolan, \{Kailey C.\} and Stone, \{Emily K.\} and Wilcher, \{Katherine E.\} and Bhakta-Yadav, \{Mili S.\} and Maxwell, \{Rose A.\} and Dhanraj, \{David N.\} and Brown, \{Thomas L.\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license. http://creativecommons.org/licenses/by-nc/4.0/",

year = "2026",

month = may,

day = "22",

doi = "10.1016/j.placenta.2026.03.020",

language = "English",

volume = "179",

pages = "40--52",

journal = "Placenta",

issn = "0143-4004",

}

TY - JOUR

T1 - Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α

AU - Johnson-Gonzalez, Courtney B.

AU - Bowman-Gibson, Scout

AU - Chandiramani, Chandni H.

AU - Linkous, Bryce A.

AU - Nolan, Kailey C.

AU - Stone, Emily K.

AU - Wilcher, Katherine E.

AU - Bhakta-Yadav, Mili S.

AU - Maxwell, Rose A.

AU - Dhanraj, David N.

AU - Brown, Thomas L.

PY - 2026/5/22

Y1 - 2026/5/22

KW - Cellular energy

KW - HIF-1 alpha

KW - Metabolism

KW - Placenta

KW - Preeclampsia

UR - https://www.scopus.com/pages/publications/105034814143

UR - https://www.scopus.com/pages/publications/105034814143#tab=citedBy

U2 - 10.1016/j.placenta.2026.03.020

DO - 10.1016/j.placenta.2026.03.020

M3 - Article

C2 - 41950693

AN - SCOPUS:105034814143

SN - 0143-4004

VL - 179

SP - 40

EP - 52

JO - Placenta

JF - Placenta

ER -

Severe early-onset preeclampsia is significantly associated with metabolic dysregulation and sustained elevation of placental HIF-1α

ASJC Scopus Subject Areas

Keywords

Access to Document

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