Simulation of Dendritic L-Type ca Channels’ Warm-Up Phenomenon in Spinal Motoneurons

Mohamed H. Mousa; Ahmed H. Kandil; Sherif M. Elbasiouny

doi:10.1109/CIBEC.2016.7836113

Simulation of Dendritic L-Type ca Channels’ Warm-Up Phenomenon in Spinal Motoneurons

Mohamed H. Mousa, Ahmed H. Kandil, Sherif M. Elbasiouny

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this study a computer-based model was developed to simulate the warm-up property of the low-voltage activated (LVA) L-type calcium channels. The LVA L-type calcium channel is one of two channels that mediate persistent inward currents in spinal alpha (a) motoneurons and plays an important role in integrating & modulating motor firing behaviors. This study was prompted by experimental observations that showed nonlinear and hysteretic behaviors of the LVA L-type calcium channel in a membrane patch, indicating that these nonlinear properties are part of the channel behavior. In this work, we introduce a new model for the LVA L-type calcium channel that incorporated the warm-up property. The new model has successfully reproduced experimental recordings from the membrane patch and from the whole cell. Our work provides a more accurate model of the LVA L-type calcium channel that could be used to reexamine the dendritic distribution of these channels on a-motoneurons.

Original language	English
Title of host publication	2016 8th Cairo International Biomedical Engineering Conference (CIBEC)
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	31-34
Number of pages	4
ISBN (Electronic)	9781509029877
ISBN (Print)	978-1-5090-2988-4
DOIs	https://doi.org/10.1109/CIBEC.2016.7836113
State	Published - Jan 27 2017
Event	8th Cairo International Biomedical Engineering Conference, CIBEC 2016 - Cairo, Egypt Duration: Dec 15 2016 → Dec 17 2016

Conference

Conference	8th Cairo International Biomedical Engineering Conference, CIBEC 2016
Country/Territory	Egypt
City	Cairo
Period	12/15/16 → 12/17/16

ASJC Scopus Subject Areas

Computer Science Applications
Biomedical Engineering

Keywords

Facilitation
L-type calcium channel
Motoneurons
Warm-up

Disciplines

Biomedical Engineering and Bioengineering

Access to Document

10.1109/CIBEC.2016.7836113License: Unspecified

Cite this

Simulation of Dendritic L-Type ca Channels’ Warm-Up Phenomenon in Spinal Motoneurons. / Mousa, Mohamed H.; Kandil, Ahmed H.; Elbasiouny, Sherif M.
2016 8th Cairo International Biomedical Engineering Conference (CIBEC). Institute of Electrical and Electronics Engineers Inc., 2017. p. 31-34 7836113.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mousa, MH, Kandil, AH & Elbasiouny, SM 2017, Simulation of Dendritic L-Type ca Channels’ Warm-Up Phenomenon in Spinal Motoneurons. in 2016 8th Cairo International Biomedical Engineering Conference (CIBEC)., 7836113, Institute of Electrical and Electronics Engineers Inc., pp. 31-34, 8th Cairo International Biomedical Engineering Conference, CIBEC 2016, Cairo, Egypt, 12/15/16. https://doi.org/10.1109/CIBEC.2016.7836113

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abstract = " In this study a computer-based model was developed to simulate the warm-up property of the low-voltage activated (LVA) L-type calcium channels. The LVA L-type calcium channel is one of two channels that mediate persistent inward currents in spinal alpha (a) motoneurons and plays an important role in integrating & modulating motor firing behaviors. This study was prompted by experimental observations that showed nonlinear and hysteretic behaviors of the LVA L-type calcium channel in a membrane patch, indicating that these nonlinear properties are part of the channel behavior. In this work, we introduce a new model for the LVA L-type calcium channel that incorporated the warm-up property. The new model has successfully reproduced experimental recordings from the membrane patch and from the whole cell. Our work provides a more accurate model of the LVA L-type calcium channel that could be used to reexamine the dendritic distribution of these channels on a-motoneurons.",

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AU - Kandil, Ahmed H.

AU - Elbasiouny, Sherif M.

PY - 2017/1/27

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N2 - In this study a computer-based model was developed to simulate the warm-up property of the low-voltage activated (LVA) L-type calcium channels. The LVA L-type calcium channel is one of two channels that mediate persistent inward currents in spinal alpha (a) motoneurons and plays an important role in integrating & modulating motor firing behaviors. This study was prompted by experimental observations that showed nonlinear and hysteretic behaviors of the LVA L-type calcium channel in a membrane patch, indicating that these nonlinear properties are part of the channel behavior. In this work, we introduce a new model for the LVA L-type calcium channel that incorporated the warm-up property. The new model has successfully reproduced experimental recordings from the membrane patch and from the whole cell. Our work provides a more accurate model of the LVA L-type calcium channel that could be used to reexamine the dendritic distribution of these channels on a-motoneurons.

AB - In this study a computer-based model was developed to simulate the warm-up property of the low-voltage activated (LVA) L-type calcium channels. The LVA L-type calcium channel is one of two channels that mediate persistent inward currents in spinal alpha (a) motoneurons and plays an important role in integrating & modulating motor firing behaviors. This study was prompted by experimental observations that showed nonlinear and hysteretic behaviors of the LVA L-type calcium channel in a membrane patch, indicating that these nonlinear properties are part of the channel behavior. In this work, we introduce a new model for the LVA L-type calcium channel that incorporated the warm-up property. The new model has successfully reproduced experimental recordings from the membrane patch and from the whole cell. Our work provides a more accurate model of the LVA L-type calcium channel that could be used to reexamine the dendritic distribution of these channels on a-motoneurons.

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BT - 2016 8th Cairo International Biomedical Engineering Conference (CIBEC)

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Simulation of Dendritic L-Type ca Channels’ Warm-Up Phenomenon in Spinal Motoneurons

Abstract

Conference

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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