Abstract
In this study a computer-based model was developed to simulate the warm-up property of the low-voltage activated (LVA) L-type calcium channels. The LVA L-type calcium channel is one of two channels that mediate persistent inward currents in spinal alpha (a) motoneurons and plays an important role in integrating & modulating motor firing behaviors. This study was prompted by experimental observations that showed nonlinear and hysteretic behaviors of the LVA L-type calcium channel in a membrane patch, indicating that these nonlinear properties are part of the channel behavior. In this work, we introduce a new model for the LVA L-type calcium channel that incorporated the warm-up property. The new model has successfully reproduced experimental recordings from the membrane patch and from the whole cell. Our work provides a more accurate model of the LVA L-type calcium channel that could be used to reexamine the dendritic distribution of these channels on a-motoneurons.
Original language | English |
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Title of host publication | 2016 8th Cairo International Biomedical Engineering Conference (CIBEC) |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 31-34 |
Number of pages | 4 |
ISBN (Electronic) | 9781509029877 |
ISBN (Print) | 978-1-5090-2988-4 |
DOIs | |
State | Published - Jan 27 2017 |
Event | 8th Cairo International Biomedical Engineering Conference, CIBEC 2016 - Cairo, Egypt Duration: Dec 15 2016 → Dec 17 2016 |
Conference
Conference | 8th Cairo International Biomedical Engineering Conference, CIBEC 2016 |
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Country/Territory | Egypt |
City | Cairo |
Period | 12/15/16 → 12/17/16 |
ASJC Scopus Subject Areas
- Computer Science Applications
- Biomedical Engineering
Keywords
- Facilitation
- L-type calcium channel
- Motoneurons
- Warm-up
Disciplines
- Biomedical Engineering and Bioengineering