Simulation of Dendritic L-Type ca Channels’ Warm-Up Phenomenon in Spinal Motoneurons

Mohamed H. Mousa, Ahmed H. Kandil, Sherif M. Elbasiouny

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study a computer-based model was developed to simulate the warm-up property of the low-voltage activated (LVA) L-type calcium channels. The LVA L-type calcium channel is one of two channels that mediate persistent inward currents in spinal alpha (a) motoneurons and plays an important role in integrating & modulating motor firing behaviors. This study was prompted by experimental observations that showed nonlinear and hysteretic behaviors of the LVA L-type calcium channel in a membrane patch, indicating that these nonlinear properties are part of the channel behavior. In this work, we introduce a new model for the LVA L-type calcium channel that incorporated the warm-up property. The new model has successfully reproduced experimental recordings from the membrane patch and from the whole cell. Our work provides a more accurate model of the LVA L-type calcium channel that could be used to reexamine the dendritic distribution of these channels on a-motoneurons.

Original languageEnglish
Title of host publication2016 8th Cairo International Biomedical Engineering Conference (CIBEC)
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages31-34
Number of pages4
ISBN (Electronic)9781509029877
ISBN (Print)978-1-5090-2988-4
DOIs
StatePublished - Jan 27 2017
Event8th Cairo International Biomedical Engineering Conference, CIBEC 2016 - Cairo, Egypt
Duration: Dec 15 2016Dec 17 2016

Conference

Conference8th Cairo International Biomedical Engineering Conference, CIBEC 2016
Country/TerritoryEgypt
CityCairo
Period12/15/1612/17/16

ASJC Scopus Subject Areas

  • Computer Science Applications
  • Biomedical Engineering

Keywords

  • Facilitation
  • L-type calcium channel
  • Motoneurons
  • Warm-up

Disciplines

  • Biomedical Engineering and Bioengineering

Cite this