The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid

Jedediah H May; Geoffrey R Rieser; Chad Williams; Ronald J Markert; Ryan D Bauman; Matthew W. Lawless

doi:10.1016/j.arth.2016.04.018

The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid

Jedediah H May, Geoffrey R Rieser, Chad Williams, Ronald J Markert, Ryan D Bauman, Matthew W. Lawless

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

<p> <h3 id="x-x-sectitle0015"> Background </h3> <p id="x-x-abspara0010"> Administration of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tranexamic-acid" title="Learn more about Tranexamic Acid from ScienceDirect's AI-generated Topic Pages"> tranexamic acid </a> topically and intravenously has demonstrated effectiveness in decreasing <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/blood-transfusion" title="Learn more about Blood Transfusion from ScienceDirect's AI-generated Topic Pages"> blood loss and transfusion </a> rates. <h3 id="x-x-sectitle0020"> Methods </h3> <p id="x-x-abspara0015"> We randomized 131 patients undergoing primary <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/total-knee-arthroplasty" title="Learn more about Total Knee Arthroplasty from ScienceDirect's AI-generated Topic Pages"> total knee arthroplasty </a> to receive either intracapsular (69) or intravenous tranexamic acid (62). <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/postoperative-hemorrhage" title="Learn more about Postoperative Hemorrhage from ScienceDirect's AI-generated Topic Pages"> Postoperative blood loss </a> was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay. <h3 id="x-x-sectitle0025"> Results </h3> <p id="x-x-abspara0020"> We found no statistically significant difference on calculated blood loss (postoperative day [POD] 1: 624 ± 326 vs 644 ± 292; <em> P </em> = .71, POD 2: 806 ± 368 vs 835 ± 319; <em> P </em> = .64, and POD 3: 1076 ± 419 vs 978 ± 343; <em> P </em> = .55). There was no difference in number of blood transfusions, length of stay, or complications. <h3 id="x-x-sectitle0030"> Conclusion </h3> <p id="x-x-abspara0025"> Intracapsular tranexamic acid is not inferior to intravenous tranexamic acid in decreasing blood loss and blood transfusion rate in primary total knee arthroplasty. </p> </p> </p> </p></p>

Original language	American English
Journal	The Journal of Arthroplasty
Volume	31
DOIs	https://doi.org/10.1016/j.arth.2016.04.018
State	Published - Apr 1 2016

Keywords

Tranexamic Acid
Total Knee Arthroplasty
Intra-articular
Intrascapsular
Intraveneous
Blood Conservation

Disciplines

Internal Medicine
Medical Specialties
Medicine and Health Sciences

Access to Document

10.1016/j.arth.2016.04.018License: CC BY

Cite this

@article{ad7e07466a2541edb7ef6b38f3551429,

title = "The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid",

abstract = " Background Administration of tranexamic acid topically and intravenously has demonstrated effectiveness in decreasing blood loss and transfusion rates. Methods We randomized 131 patients undergoing primary total knee arthroplasty to receive either intracapsular (69) or intravenous tranexamic acid (62). Postoperative blood loss was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay. Results We found no statistically significant difference on calculated blood loss (postoperative day [POD] 1: 624 ± 326 vs 644 ± 292; P = .71, POD 2: 806 ± 368 vs 835 ± 319; P = .64, and POD 3: 1076 ± 419 vs 978 ± 343; P = .55). There was no difference in number of blood transfusions, length of stay, or complications. Conclusion Intracapsular tranexamic acid is not inferior to intravenous tranexamic acid in decreasing blood loss and blood transfusion rate in primary total knee arthroplasty. ",

keywords = "Tranexamic Acid, Total Knee Arthroplasty, Intra-articular, Intrascapsular, Intraveneous, Blood Conservation",

author = "May, {Jedediah H} and Rieser, {Geoffrey R} and Chad Williams and Markert, {Ronald J} and Bauman, {Ryan D} and Lawless, {Matthew W.}",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.arth.2016.04.018",

language = "American English",

volume = "31",

journal = "The Journal of Arthroplasty",

}

TY - JOUR

T1 - The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid

AU - May, Jedediah H

AU - Rieser, Geoffrey R

AU - Williams, Chad

AU - Markert, Ronald J

AU - Bauman, Ryan D

AU - Lawless, Matthew W.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Administration of tranexamic acid topically and intravenously has demonstrated effectiveness in decreasing blood loss and transfusion rates. Methods We randomized 131 patients undergoing primary total knee arthroplasty to receive either intracapsular (69) or intravenous tranexamic acid (62). Postoperative blood loss was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay. Results We found no statistically significant difference on calculated blood loss (postoperative day [POD] 1: 624 ± 326 vs 644 ± 292; P = .71, POD 2: 806 ± 368 vs 835 ± 319; P = .64, and POD 3: 1076 ± 419 vs 978 ± 343; P = .55). There was no difference in number of blood transfusions, length of stay, or complications. Conclusion Intracapsular tranexamic acid is not inferior to intravenous tranexamic acid in decreasing blood loss and blood transfusion rate in primary total knee arthroplasty.

AB - Background Administration of tranexamic acid topically and intravenously has demonstrated effectiveness in decreasing blood loss and transfusion rates. Methods We randomized 131 patients undergoing primary total knee arthroplasty to receive either intracapsular (69) or intravenous tranexamic acid (62). Postoperative blood loss was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay. Results We found no statistically significant difference on calculated blood loss (postoperative day [POD] 1: 624 ± 326 vs 644 ± 292; P = .71, POD 2: 806 ± 368 vs 835 ± 319; P = .64, and POD 3: 1076 ± 419 vs 978 ± 343; P = .55). There was no difference in number of blood transfusions, length of stay, or complications. Conclusion Intracapsular tranexamic acid is not inferior to intravenous tranexamic acid in decreasing blood loss and blood transfusion rate in primary total knee arthroplasty.

KW - Tranexamic Acid

KW - Total Knee Arthroplasty

KW - Intra-articular

KW - Intrascapsular

KW - Intraveneous

KW - Blood Conservation

UR - https://corescholar.libraries.wright.edu/orthopaedics/5

U2 - 10.1016/j.arth.2016.04.018

DO - 10.1016/j.arth.2016.04.018

M3 - Article

C2 - 27259391

VL - 31

JO - The Journal of Arthroplasty

JF - The Journal of Arthroplasty

ER -

The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Cite this