The Continuing Case for the Renshaw Cell

Francisco J. Alvarez; Robert E.W. Fyffe

doi:10.1113/physiol.2007.136200

The Continuing Case for the Renshaw Cell

Francisco J. Alvarez, Robert E.W. Fyffe

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Contribution to journal › Article › peer-review

Abstract

Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.

Original language	American English
Journal	The Journal of Physiology
Volume	584
DOIs	https://doi.org/10.1113/physiol.2007.136200
State	Published - Oct 1 2007

Keywords

MAMMALIAN SPINAL-CORD
LIGHT MICROSCOPIC OBSERVATIONS
LOCOMOTOR PATTERN GENERATION
RECURRENT INHIBITION
MOTOR-NEURONS
HORSERADISH-PEROXIDASE
SYNAPTIC CURRENTS
GLYCINE RECEPTOR
TRANSCRIPTIONAL CODES
POSTNATAL MATURATION

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

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10.1113/physiol.2007.136200License: CC BY

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277064/pdf/tjp0584-0031.pdf

Cite this

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title = "The Continuing Case for the Renshaw Cell",

abstract = " Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.",

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author = "Alvarez, \{Francisco J.\} and Fyffe, \{Robert E.W.\}",

year = "2007",

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doi = "10.1113/physiol.2007.136200",

language = "American English",

volume = "584",

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AU - Fyffe, Robert E.W.

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AB - Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.

KW - MAMMALIAN SPINAL-CORD

KW - LIGHT MICROSCOPIC OBSERVATIONS

KW - LOCOMOTOR PATTERN GENERATION

KW - RECURRENT INHIBITION

KW - MOTOR-NEURONS

KW - HORSERADISH-PEROXIDASE

KW - SYNAPTIC CURRENTS

KW - GLYCINE RECEPTOR

KW - TRANSCRIPTIONAL CODES

KW - POSTNATAL MATURATION

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UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277064/pdf/tjp0584-0031.pdf

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DO - 10.1113/physiol.2007.136200

M3 - Article

C2 - 17640932

VL - 584

JO - The Journal of Physiology

JF - The Journal of Physiology

ER -

The Continuing Case for the Renshaw Cell

Abstract

Keywords

Disciplines

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