The Effect of Methanandamide on Isolated Type I Cells

Christopher N. Wyatt; Keith J. Buckler

doi:10.1007/978-1-4419-9280-2_15

The Effect of Methanandamide on Isolated Type I Cells

Christopher N. Wyatt, Keith J. Buckler

Neuroscience, Cell Biology, and Physiology (NCBP)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Previous work from this laboratory has demonstrated that hypoxia inhibits a TASK-1 like background K+ current in isolated neonatal rat carotid body type I cells. This inhibition leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler et al 2000). Maingret et al (2000) have demonstrated that the endocannabinoid anandamide was a direct and selective blocker of TASK-1. Therefore, in this study we have investigated the actions of anandamide and its analogue methanandamide on isolated type I cells.

Original language	English
Title of host publication	Chemoreception
Subtitle of host publication	From Cellular Signaling to Functional Plasticity
Editors	Jean-Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yvette Dalmaz
Publisher	Springer New York
Pages	123-127
Number of pages	5
Edition	1
ISBN (Electronic)	978-1-4419-9280-2
ISBN (Print)	978-1-4613-4873-3, 978-0-306-47868-0
DOIs	https://doi.org/10.1007/978-1-4419-9280-2_15
State	Published - 2003
Event	15th International Society of Arterial Chemoreception Symposium - Lyon, France Duration: Nov 18 2002 → Nov 22 2002 Conference number: 15

Publication series

Name	Advances in Experimental Medicine and Biology
ISSN (Print)	0065-2598

Conference

Conference	15th International Society of Arterial Chemoreception Symposium
Abbreviated title	15th ISAC Symposium
Country/Territory	France
City	Lyon
Period	11/18/02 → 11/22/02

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

methanandamide
Animals
Arachidonic Acids
Carotid Body
Cell Hypoxia
Male
Membrane Potentials
Oxygen
Polyunsaturated Alkamides
Rats

Disciplines

Cell Biology

Access to Document

10.1007/978-1-4419-9280-2_15

Cite this

Wyatt, C. N., & Buckler, K. J. (2003). The Effect of Methanandamide on Isolated Type I Cells. In J.-M. Pequignot, C. Gonzalez, C. A. Nurse, N. R. Prabhakar, & Y. Dalmaz (Eds.), Chemoreception: From Cellular Signaling to Functional Plasticity (1 ed., pp. 123-127). (Advances in Experimental Medicine and Biology). Springer New York. https://doi.org/10.1007/978-1-4419-9280-2_15

The Effect of Methanandamide on Isolated Type I Cells. / Wyatt, Christopher N.; Buckler, Keith J.
Chemoreception: From Cellular Signaling to Functional Plasticity. ed. / Jean-Marc Pequignot; Constancio Gonzalez; Colin A. Nurse; Nanduri R. Prabhakar; Yvette Dalmaz. 1. ed. Springer New York, 2003. p. 123-127 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wyatt, CN & Buckler, KJ 2003, The Effect of Methanandamide on Isolated Type I Cells. in J-M Pequignot, C Gonzalez, CA Nurse, NR Prabhakar & Y Dalmaz (eds), Chemoreception: From Cellular Signaling to Functional Plasticity. 1 edn, Advances in Experimental Medicine and Biology, Springer New York, pp. 123-127, 15th International Society of Arterial Chemoreception Symposium, Lyon, France, 11/18/02. https://doi.org/10.1007/978-1-4419-9280-2_15

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abstract = "Previous work from this laboratory has demonstrated that hypoxia inhibits a TASK-1 like background K+ current in isolated neonatal rat carotid body type I cells. This inhibition leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler et al 2000). Maingret et al (2000) have demonstrated that the endocannabinoid anandamide was a direct and selective blocker of TASK-1. Therefore, in this study we have investigated the actions of anandamide and its analogue methanandamide on isolated type I cells.",

keywords = "methanandamide, Animals, Arachidonic Acids, Carotid Body, Cell Hypoxia, Male, Membrane Potentials, Oxygen, Polyunsaturated Alkamides, Rats",

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AB - Previous work from this laboratory has demonstrated that hypoxia inhibits a TASK-1 like background K+ current in isolated neonatal rat carotid body type I cells. This inhibition leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler et al 2000). Maingret et al (2000) have demonstrated that the endocannabinoid anandamide was a direct and selective blocker of TASK-1. Therefore, in this study we have investigated the actions of anandamide and its analogue methanandamide on isolated type I cells.

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KW - Arachidonic Acids

KW - Carotid Body

KW - Cell Hypoxia

KW - Male

KW - Membrane Potentials

KW - Oxygen

KW - Polyunsaturated Alkamides

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ER -

The Effect of Methanandamide on Isolated Type I Cells

Abstract

Publication series

Conference

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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