The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes

THE PREP-IT Investigators; Executive Committee; Steering Committee; Adjudication Committee; Data and Safety Monitoring Committee; Research Methodology Core; Patient Centred Outcomes Core; Orthopaedic Surgery Core; Operating Room Core; Infectious Disease Core; Military Core; McMaster University Methods Center (Hamilton, ON); University of Maryland School of Medicine Administrative Center (Baltimore, MD); University of Maryland School of Pharmacy, The PATIENTS Program (Baltimore, MD); PREP-IT Clinical Sites; Lead Clinical Site (Aqueous-PREP and PREPARE); University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD; Aqueous-PREP and PREPARE; Hamilton Health Sciences – General Site, Hamilton, ON; Prisma Health - Upstate, Greenville, SC; IU Health Methodist Hospital, Indianapolis, IN; San Antonio Military Medical Center, San Antonio, TX; University of California, San Francisco, San Francisco, CA; Aqueous-PREP; Vanderbilt Medical Center, Nashville, TN; University of Florida, Gainesville, FL; McGovern Medical School at UTHealth Houston, Houston, TX; Wright State University, Dayton, OH; Banner University Medical Center – Tucson, Tucson, AZ; The CORE Institute, Phoenix, AZ; Vall d'Hebron University Hospital, Barcelona, Spain; Hospital Universitari Parc Tauli, Barcelona, Spain; PREPARE; FRASER HEALTH AUTHORITY/Royal Columbian Hospital, New Westminster, BC; Inova Fairfax Medical Campus, Falls Church, VA; Wake Forest Baptist Health, Winston-Salem, NC; MetroHealth Medical Center, Cleveland, OH; University of Utah, Salt Lake City, Utah; University of Mississippi Medical Center, Jackson, MS; Sanford Health, Sioux Falls, SD; Dartmouth-Hitchcock Medical Center, Lebanon, NH; Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC; University of Maryland, Capital Region Health, Largo, MD; University of Wisconsin Madison, Madison, WI; Duke University Hospital, Durham, NC; Brigham Women's Hospital, Boston, MA; University of Pennsylvania, Philadelphia, PA; Massachusetts General Hospital, Boston, MA; Bryan Medical Center, Lincoln, Nebraska; University of Cincinnati, Cincinnati, OH; Cedars-Sinai Medical Center, Los Angeles, CA; University of California, Irvine, Orange, CA

doi:10.1016/j.injury.2023.03.001

The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes

THE PREP-IT Investigators, Executive Committee, Steering Committee, Adjudication Committee, Data and Safety Monitoring Committee, Research Methodology Core, Patient Centred Outcomes Core, Orthopaedic Surgery Core, Operating Room Core, Infectious Disease Core, Military Core, McMaster University Methods Center (Hamilton, ON), University of Maryland School of Medicine Administrative Center (Baltimore, MD), University of Maryland School of Pharmacy, The PATIENTS Program (Baltimore, MD), PREP-IT Clinical Sites, Lead Clinical Site (Aqueous-PREP and PREPARE), University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD, Aqueous-PREP and PREPARE, Hamilton Health Sciences – General Site, Hamilton, ON, Prisma Health - Upstate, Greenville, SCIU Health Methodist Hospital, Indianapolis, IN, San Antonio Military Medical Center, San Antonio, TX, University of California, San Francisco, San Francisco, CA, Aqueous-PREP, Vanderbilt Medical Center, Nashville, TN, University of Florida, Gainesville, FL, McGovern Medical School at UTHealth Houston, Houston, TX, Wright State University, Dayton, OH, Banner University Medical Center – Tucson, Tucson, AZ, The CORE Institute, Phoenix, AZ, Vall d'Hebron University Hospital, Barcelona, Spain, Hospital Universitari Parc Tauli, Barcelona, Spain, PREPARE, FRASER HEALTH AUTHORITY/Royal Columbian Hospital, New Westminster, BC, Inova Fairfax Medical Campus, Falls Church, VA, Wake Forest Baptist Health, Winston-Salem, NC, MetroHealth Medical Center, Cleveland, OH, University of Utah, Salt Lake City, Utah, University of Mississippi Medical Center, Jackson, MS, Sanford Health, Sioux Falls, SD, Dartmouth-Hitchcock Medical Center, Lebanon, NH, Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC, University of Maryland, Capital Region Health, Largo, MD, University of Wisconsin Madison, Madison, WI, Duke University Hospital, Durham, NC, Brigham Women's Hospital, Boston, MA, University of Pennsylvania, Philadelphia, PA, Massachusetts General Hospital, Boston, MA, Bryan Medical Center, Lincoln, Nebraska, University of Cincinnati, Cincinnati, OH, Cedars-Sinai Medical Center, Los Angeles, CA, University of California, Irvine, Orange, CA

Orthopaedic and Plastic Surgery

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1693-1701
Number of pages	9
Journal	Injury Extra
Volume	54
Issue number	6
DOIs	https://doi.org/10.1016/j.injury.2023.03.001
State	Published - Jun 2023

ASJC Scopus Subject Areas

Emergency Medicine
Orthopedics and Sports Medicine

Keywords

Acetabular fractures
Heterotopic ossification
Indomethacin prophylaxis
XRT prophylaxis

Access to Document

10.1016/j.injury.2023.03.001

Cite this

THE PREP-IT Investigators, Executive Committee, Steering Committee, Adjudication Committee, Data and Safety Monitoring Committee, Research Methodology Core, Patient Centred Outcomes Core, Orthopaedic Surgery Core, Operating Room Core, Infectious Disease Core, Military Core, McMaster University Methods Center (Hamilton, ON), University of Maryland School of Medicine Administrative Center (Baltimore, MD), University of Maryland School of Pharmacy, The PATIENTS Program (Baltimore, MD), PREP-IT Clinical Sites, Lead Clinical Site (Aqueous-PREP and PREPARE), University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD, Aqueous-PREP and PREPARE, Hamilton Health Sciences – General Site, Hamilton, ON, ... University of California, Irvine, Orange, CA (2023). The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes. Injury Extra, 54(6), 1693-1701. https://doi.org/10.1016/j.injury.2023.03.001

THE PREP-IT Investigators, Executive Committee, Steering Committee, Adjudication Committee, Data and Safety Monitoring Committee, Research Methodology Core, Patient Centred Outcomes Core, Orthopaedic Surgery Core, Operating Room Core, Infectious Disease Core, Military Core, McMaster University Methods Center (Hamilton, ON), University of Maryland School of Medicine Administrative Center (Baltimore, MD), University of Maryland School of Pharmacy, The PATIENTS Program (Baltimore, MD), PREP-IT Clinical Sites, Lead Clinical Site (Aqueous-PREP and PREPARE), University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD, Aqueous-PREP and PREPARE, Hamilton Health Sciences – General Site, Hamilton, ON, Prisma Health - Upstate, Greenville, SC, IU Health Methodist Hospital, Indianapolis, IN, San Antonio Military Medical Center, San Antonio, TX, University of California, San Francisco, San Francisco, CA, Aqueous-PREP, Vanderbilt Medical Center, Nashville, TN, University of Florida, Gainesville, FL, McGovern Medical School at UTHealth Houston, Houston, TX, Wright State University, Dayton, OH, Banner University Medical Center – Tucson, Tucson, AZ, The CORE Institute, Phoenix, AZ, Vall d'Hebron University Hospital, Barcelona, Spain, Hospital Universitari Parc Tauli, Barcelona, Spain, PREPARE, FRASER HEALTH AUTHORITY/Royal Columbian Hospital, New Westminster, BC, Inova Fairfax Medical Campus, Falls Church, VA, Wake Forest Baptist Health, Winston-Salem, NC, MetroHealth Medical Center, Cleveland, OH, University of Utah, Salt Lake City, Utah, University of Mississippi Medical Center, Jackson, MS, Sanford Health, Sioux Falls, SD, Dartmouth-Hitchcock Medical Center, Lebanon, NH, Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC, University of Maryland, Capital Region Health, Largo, MD, University of Wisconsin Madison, Madison, WI, Duke University Hospital, Durham, NC, Brigham Women's Hospital, Boston, MA, University of Pennsylvania, Philadelphia, PA, Massachusetts General Hospital, Boston, MA, Bryan Medical Center, Lincoln, Nebraska, University of Cincinnati, Cincinnati, OH, Cedars-Sinai Medical Center, Los Angeles, CA & University of California, Irvine, Orange, CA 2023, 'The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes', Injury Extra, vol. 54, no. 6, pp. 1693-1701. https://doi.org/10.1016/j.injury.2023.03.001

THE PREP-IT Investigators, Executive Committee, Steering Committee, Adjudication Committee, Data and Safety Monitoring Committee, Research Methodology Core et al. The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes. Injury Extra. 2023 Jun;54(6):1693-1701. doi: 10.1016/j.injury.2023.03.001

@article{d01e4f366b8143f096c3fcd8df5c7e2e,

title = "The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes",

keywords = "Acetabular fractures, Heterotopic ossification, Indomethacin prophylaxis, XRT prophylaxis",

author = "{THE PREP-IT Investigators} and {Executive Committee} and {Steering Committee} and {Adjudication Committee} and {Data and Safety Monitoring Committee} and {Research Methodology Core} and {Patient Centred Outcomes Core} and {Orthopaedic Surgery Core} and {Operating Room Core} and {Infectious Disease Core} and {Military Core} and {McMaster University Methods Center (Hamilton, ON)} and {University of Maryland School of Medicine Administrative Center (Baltimore, MD)} and {University of Maryland School of Pharmacy, The PATIENTS Program (Baltimore, MD)} and {PREP-IT Clinical Sites} and {Lead Clinical Site (Aqueous-PREP and PREPARE)} and {University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD} and {Aqueous-PREP and PREPARE} and {Hamilton Health Sciences – General Site, Hamilton, ON} and {Prisma Health - Upstate, Greenville, SC} and {IU Health Methodist Hospital, Indianapolis, IN} and {San Antonio Military Medical Center, San Antonio, TX} and {University of California, San Francisco, San Francisco, CA} and Aqueous-PREP and {Vanderbilt Medical Center, Nashville, TN} and {University of Florida, Gainesville, FL} and {McGovern Medical School at UTHealth Houston, Houston, TX} and {Wright State University, Dayton, OH} and {Banner University Medical Center – Tucson, Tucson, AZ} and {The CORE Institute, Phoenix, AZ} and {Vall d'Hebron University Hospital, Barcelona, Spain} and {Hospital Universitari Parc Tauli, Barcelona, Spain} and PREPARE and {FRASER HEALTH AUTHORITY/Royal Columbian Hospital, New Westminster, BC} and {Inova Fairfax Medical Campus, Falls Church, VA} and {Wake Forest Baptist Health, Winston-Salem, NC} and {MetroHealth Medical Center, Cleveland, OH} and {University of Utah, Salt Lake City, Utah} and {University of Mississippi Medical Center, Jackson, MS} and {Sanford Health, Sioux Falls, SD} and {Dartmouth-Hitchcock Medical Center, Lebanon, NH} and {Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC} and {University of Maryland, Capital Region Health, Largo, MD} and {University of Wisconsin Madison, Madison, WI} and {Duke University Hospital, Durham, NC} and {Brigham Women's Hospital, Boston, MA} and {University of Pennsylvania, Philadelphia, PA} and {Massachusetts General Hospital, Boston, MA} and {Bryan Medical Center, Lincoln, Nebraska} and {University of Cincinnati, Cincinnati, OH} and {Cedars-Sinai Medical Center, Los Angeles, CA} and {University of California, Irvine, Orange, CA} and Adam Boissonneault and {O Hara}, Nathan and David Pogorzelski and Lucas Marchand and Thomas Higgins and Leah Gitajn and Gage, {Mark J.} and Natoli, {Roman M.} and Ishani Sharma and Sarah Pierrie and O'Toole, {Robert V.} and Sheila Sprague and Gerard Slobogean and Slobogean, {Gerard P.} and Jeffrey Wells and Mohit Bhandari and Harris, {Anthony D.} and Mullins, {C. Daniel} and Lehana Thabane and Amber Wood and Rocca, {Gregory J.Della} and Joan Hebden and Jeray, {Kyle J.} and Marchand, {Lucas S.} and O'Hara, {Lyndsay M.} and Robert Zura and Christopher Lee and Joseph Patterson and Gardner, {Michael J.} and Jenna Blasman and Jonah Davies and Stephen Liang and Monica Taljaard and Devereaux, {P. J.} and Guyatt, {Gordon H.} and Diane Heels-Ansdell and Debra Marvel and Wells, {Jana Palmer Jeffrey} and Jeff Friedrich and O'Hara, {Nathan N.} and Frances Grissom and Gitajn, {I. Leah} and Saam Morshed and O'Toole, {Robert V.} and Petrisor, {Bradley A.} and Franca Mossuto and Michael Prayson and Brandon Horne and Jennifer Jerele and Laughlin, {Richard T.}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = jun,

doi = "10.1016/j.injury.2023.03.001",

language = "English",

volume = "54",

pages = "1693--1701",

journal = "Injury Extra",

issn = "0020-1383",

number = "6",

}

TY - JOUR

T1 - The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures

T2 - national treatment patterns and related outcomes

AU - THE PREP-IT Investigators

AU - Executive Committee

AU - Steering Committee

AU - Adjudication Committee

AU - Data and Safety Monitoring Committee

AU - Research Methodology Core

AU - Patient Centred Outcomes Core

AU - Orthopaedic Surgery Core

AU - Operating Room Core

AU - Infectious Disease Core

AU - Military Core

AU - McMaster University Methods Center (Hamilton, ON)

AU - University of Maryland School of Medicine Administrative Center (Baltimore, MD)

AU - University of Maryland School of Pharmacy, The PATIENTS Program (Baltimore, MD)

AU - PREP-IT Clinical Sites

AU - Lead Clinical Site (Aqueous-PREP and PREPARE)

AU - University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD

AU - Aqueous-PREP and PREPARE

AU - Hamilton Health Sciences – General Site, Hamilton, ON

AU - Prisma Health - Upstate, Greenville, SC

AU - IU Health Methodist Hospital, Indianapolis, IN

AU - San Antonio Military Medical Center, San Antonio, TX

AU - University of California, San Francisco, San Francisco, CA

AU - Aqueous-PREP

AU - Vanderbilt Medical Center, Nashville, TN

AU - University of Florida, Gainesville, FL

AU - McGovern Medical School at UTHealth Houston, Houston, TX

AU - Wright State University, Dayton, OH

AU - Banner University Medical Center – Tucson, Tucson, AZ

AU - The CORE Institute, Phoenix, AZ

AU - Vall d'Hebron University Hospital, Barcelona, Spain

AU - Hospital Universitari Parc Tauli, Barcelona, Spain

AU - PREPARE

AU - FRASER HEALTH AUTHORITY/Royal Columbian Hospital, New Westminster, BC

AU - Inova Fairfax Medical Campus, Falls Church, VA

AU - Wake Forest Baptist Health, Winston-Salem, NC

AU - MetroHealth Medical Center, Cleveland, OH

AU - University of Utah, Salt Lake City, Utah

AU - University of Mississippi Medical Center, Jackson, MS

AU - Sanford Health, Sioux Falls, SD

AU - Dartmouth-Hitchcock Medical Center, Lebanon, NH

AU - Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC

AU - University of Maryland, Capital Region Health, Largo, MD

AU - University of Wisconsin Madison, Madison, WI

AU - Duke University Hospital, Durham, NC

AU - Brigham Women's Hospital, Boston, MA

AU - University of Pennsylvania, Philadelphia, PA

AU - Massachusetts General Hospital, Boston, MA

AU - Bryan Medical Center, Lincoln, Nebraska

AU - University of Cincinnati, Cincinnati, OH

AU - Cedars-Sinai Medical Center, Los Angeles, CA

AU - University of California, Irvine, Orange, CA

AU - Boissonneault, Adam

AU - O Hara, Nathan

AU - Pogorzelski, David

AU - Marchand, Lucas

AU - Higgins, Thomas

AU - Gitajn, Leah

AU - Gage, Mark J.

AU - Natoli, Roman M.

AU - Sharma, Ishani

AU - Pierrie, Sarah

AU - O'Toole, Robert V.

AU - Sprague, Sheila

AU - Slobogean, Gerard

AU - Slobogean, Gerard P.

AU - Wells, Jeffrey

AU - Bhandari, Mohit

AU - Harris, Anthony D.

AU - Mullins, C. Daniel

AU - Thabane, Lehana

AU - Wood, Amber

AU - Rocca, Gregory J.Della

AU - Hebden, Joan

AU - Jeray, Kyle J.

AU - Marchand, Lucas S.

AU - O'Hara, Lyndsay M.

AU - Zura, Robert

AU - Lee, Christopher

AU - Patterson, Joseph

AU - Gardner, Michael J.

AU - Blasman, Jenna

AU - Davies, Jonah

AU - Liang, Stephen

AU - Taljaard, Monica

AU - Devereaux, P. J.

AU - Guyatt, Gordon H.

AU - Heels-Ansdell, Diane

AU - Marvel, Debra

AU - Wells, Jana Palmer Jeffrey

AU - Friedrich, Jeff

AU - O'Hara, Nathan N.

AU - Grissom, Frances

AU - Gitajn, I. Leah

AU - Morshed, Saam

AU - O'Toole, Robert V.

AU - Petrisor, Bradley A.

AU - Mossuto, Franca

AU - Prayson, Michael

AU - Horne, Brandon

AU - Jerele, Jennifer

AU - Laughlin, Richard T.

PY - 2023/6

Y1 - 2023/6

KW - Acetabular fractures

KW - Heterotopic ossification

KW - Indomethacin prophylaxis

KW - XRT prophylaxis

UR - http://www.scopus.com/inward/record.url?scp=85151292751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85151292751&partnerID=8YFLogxK

U2 - 10.1016/j.injury.2023.03.001

DO - 10.1016/j.injury.2023.03.001

M3 - Article

C2 - 37002119

AN - SCOPUS:85151292751

SN - 0020-1383

VL - 54

SP - 1693

EP - 1701

JO - Injury Extra

JF - Injury Extra

IS - 6

ER -

The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Cite this