The Rho(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas

Nancy J. Bigley; Matthew C. Dodd; Chester I. Randles; Virginia B. Geyer; Alvin G. Lazen

The Rh_o(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas

Nancy J. Bigley, Matthew C. Dodd, Chester I. Randles, Virginia B. Geyer, Alvin G. Lazen

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

A polysaccharide from an unidentified species of Pseudomonas (PsP) has been shown to possess antigenic specificity similar to the Rh _o (D) antigen of human red cells. The following findings revealed this specificity: a) PsP inhibited anti-D agglutinins; b) anti-PsP rabbit sera contained both saline agglutinins and incomplete antibodies specific only for cells containing D antigen; c) D-positive cells absorbed specific agglutinins from anti-PsP sera; d) anti-D serum blocked agglutination of D cells by anti-PsP serum. Agglutination of D cells by anti-PsP rabbit serum was inhibited by N -acetylneuraminic acid (NANA) containing substances different from those previously shown to inhibit D cell agglutination by specific Rh antiserum. It was concluded that the antigenic similarity is not due to NANA but to some structure or linkage resembling it.

Original language	American English
Journal	The Journal of Immunology
Volume	90
State	Published - Apr 1 1963

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

Access to Document

http://www.jimmunol.org/content/90/4/526

Cite this

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title = "The Rho(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas",

abstract = " A polysaccharide from an unidentified species of Pseudomonas (PsP) has been shown to possess antigenic specificity similar to the Rh o (D) antigen of human red cells. The following findings revealed this specificity: a) PsP inhibited anti-D agglutinins; b) anti-PsP rabbit sera contained both saline agglutinins and incomplete antibodies specific only for cells containing D antigen; c) D-positive cells absorbed specific agglutinins from anti-PsP sera; d) anti-D serum blocked agglutination of D cells by anti-PsP serum. Agglutination of D cells by anti-PsP rabbit serum was inhibited by N -acetylneuraminic acid (NANA) containing substances different from those previously shown to inhibit D cell agglutination by specific Rh antiserum. It was concluded that the antigenic similarity is not due to NANA but to some structure or linkage resembling it.",

author = "Bigley, {Nancy J.} and Dodd, {Matthew C.} and Randles, {Chester I.} and Geyer, {Virginia B.} and Lazen, {Alvin G.}",

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T1 - The Rho(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas

AU - Bigley, Nancy J.

AU - Dodd, Matthew C.

AU - Randles, Chester I.

AU - Geyer, Virginia B.

AU - Lazen, Alvin G.

PY - 1963/4/1

Y1 - 1963/4/1

N2 - A polysaccharide from an unidentified species of Pseudomonas (PsP) has been shown to possess antigenic specificity similar to the Rh o (D) antigen of human red cells. The following findings revealed this specificity: a) PsP inhibited anti-D agglutinins; b) anti-PsP rabbit sera contained both saline agglutinins and incomplete antibodies specific only for cells containing D antigen; c) D-positive cells absorbed specific agglutinins from anti-PsP sera; d) anti-D serum blocked agglutination of D cells by anti-PsP serum. Agglutination of D cells by anti-PsP rabbit serum was inhibited by N -acetylneuraminic acid (NANA) containing substances different from those previously shown to inhibit D cell agglutination by specific Rh antiserum. It was concluded that the antigenic similarity is not due to NANA but to some structure or linkage resembling it.

AB - A polysaccharide from an unidentified species of Pseudomonas (PsP) has been shown to possess antigenic specificity similar to the Rh o (D) antigen of human red cells. The following findings revealed this specificity: a) PsP inhibited anti-D agglutinins; b) anti-PsP rabbit sera contained both saline agglutinins and incomplete antibodies specific only for cells containing D antigen; c) D-positive cells absorbed specific agglutinins from anti-PsP sera; d) anti-D serum blocked agglutination of D cells by anti-PsP serum. Agglutination of D cells by anti-PsP rabbit serum was inhibited by N -acetylneuraminic acid (NANA) containing substances different from those previously shown to inhibit D cell agglutination by specific Rh antiserum. It was concluded that the antigenic similarity is not due to NANA but to some structure or linkage resembling it.

UR - https://corescholar.libraries.wright.edu/ncbp/494

UR - http://www.jimmunol.org/content/90/4/526

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