TY - CHAP
T1 - Therapeutic Drug Monitoring in Pregnancy
AU - Campbell, Sarah C.
AU - Salisbury, Laura M.
AU - Roberts, Jessica K.
AU - Kamyar, Manijeh
AU - Fredrickson, Jeunesse
AU - Constantine, Maged M.
AU - Sherwin, Catherine M.T.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.
AB - During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.
UR - https://corescholar.libraries.wright.edu/pediatrics/342
UR - https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780128020258000088
M3 - Chapter
BT - Clinical Challenges in Therapeutic Drug Monitoring
ER -