Therapeutic Drug Monitoring in Pregnancy

Sarah C. Campbell; Laura M. Salisbury; Jessica K. Roberts; Manijeh Kamyar; Jeunesse Fredrickson; Maged M. Costantine; Catherine M.T. Sherwin

doi:10.1016/B978-0-12-802025-8.00008-8

Therapeutic Drug Monitoring in Pregnancy

Sarah C. Campbell, Laura M. Salisbury, Jessica K. Roberts, Manijeh Kamyar, Jeunesse Fredrickson, Maged M. Costantine, Catherine M.T. Sherwin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.

Original language	English
Title of host publication	Clinical Challenges in Therapeutic Drug Monitoring
Subtitle of host publication	Special Populations, Physiological Conditions, and Pharmacogenomics
Publisher	Elsevier Inc.
Pages	185-211
Number of pages	27
ISBN (Electronic)	9780128020524
ISBN (Print)	9780128020258
DOIs	https://doi.org/10.1016/B978-0-12-802025-8.00008-8
State	Published - May 17 2016
Externally published	Yes

ASJC Scopus Subject Areas

General Medicine

Keywords

Altered drug disposition
Anticonvulsants
Antidepressants
Cardiac drugs
Pregnancy

Disciplines

Pediatrics

Access to Document

10.1016/B978-0-12-802025-8.00008-8

Cite this

Campbell, S. C., Salisbury, L. M., Roberts, J. K., Kamyar, M., Fredrickson, J., Costantine, M. M., & Sherwin, C. M. T. (2016). Therapeutic Drug Monitoring in Pregnancy. In Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics (pp. 185-211). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802025-8.00008-8

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AU - Campbell, Sarah C.

AU - Salisbury, Laura M.

AU - Roberts, Jessica K.

AU - Kamyar, Manijeh

AU - Fredrickson, Jeunesse

AU - Costantine, Maged M.

AU - Sherwin, Catherine M.T.

PY - 2016/5/17

Y1 - 2016/5/17

N2 - During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.

AB - During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.

KW - Altered drug disposition

KW - Anticonvulsants

KW - Antidepressants

KW - Cardiac drugs

KW - Pregnancy

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M3 - Chapter

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EP - 211

BT - Clinical Challenges in Therapeutic Drug Monitoring

PB - Elsevier Inc.

ER -

Therapeutic Drug Monitoring in Pregnancy

Abstract

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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Cite this