Topical Corn Oil in the Management of Essential Fatty Acid Deficiency

Mary C. McCarthy; William W. Turner; Kathleen Whatley; G. Larry Cottam

Topical Corn Oil in the Management of Essential Fatty Acid Deficiency

Mary C. McCarthy, William W. Turner, Kathleen Whatley, G. Larry Cottam

Wright State University

Research output: Contribution to journal › Article › peer-review

Abstract

Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 +/- 3.8 (mean +/- SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3[omega]9/20:4[omega]6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN. (C) Williams & Wilkins 1983. All Rights Reserved.

Original language	American English
Journal	Critical Care Medicine
Volume	11
State	Published - May 1 1983

Disciplines

Medical Specialties
Medicine and Health Sciences
Surgery

Cite this

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title = "Topical Corn Oil in the Management of Essential Fatty Acid Deficiency",

abstract = " Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 +/- 3.8 (mean +/- SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3[omega]9/20:4[omega]6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN. (C) Williams & Wilkins 1983. All Rights Reserved. ",

author = "McCarthy, {Mary C.} and Turner, {William W.} and Kathleen Whatley and Cottam, {G. Larry}",

year = "1983",

month = may,

day = "1",

language = "American English",

volume = "11",

journal = "Critical Care Medicine",

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T1 - Topical Corn Oil in the Management of Essential Fatty Acid Deficiency

AU - McCarthy, Mary C.

AU - Turner, William W.

AU - Whatley, Kathleen

AU - Cottam, G. Larry

PY - 1983/5/1

Y1 - 1983/5/1

N2 - Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 +/- 3.8 (mean +/- SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3[omega]9/20:4[omega]6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN. (C) Williams & Wilkins 1983. All Rights Reserved.

AB - Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 +/- 3.8 (mean +/- SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3[omega]9/20:4[omega]6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN. (C) Williams & Wilkins 1983. All Rights Reserved.

UR - https://corescholar.libraries.wright.edu/surg/534

M3 - Article

VL - 11

JO - Critical Care Medicine

JF - Critical Care Medicine

ER -

Topical Corn Oil in the Management of Essential Fatty Acid Deficiency

Abstract

Disciplines

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