UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects

Katherine E. Fahy; Langni Liu; Christine M. Rapp; Christina E. Borchers; Ji C. Bihl; Yanfang Chen; Richard Simman; Jeffrey B. Travers

doi:10.1111/php.12703

UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects

Katherine E. Fahy, Langni Liu, Christine M. Rapp, Christina E. Borchers, Ji C. Bihl, Yanfang Chen, Richard Simman, Jeffrey B. Travers

Research output: Contribution to journal › Article › peer-review

Abstract

Ultraviolet B radiation (UVB) exerts profound effects on human skin. Much is known regarding the ability of UVB to generate a plethora of bioactive agents ranging from cytokines and other bioactive proteins, lipid mediators and microRNAs. It is presumed that these agents are in large part responsible for the effects of UVB, which is only absorbed appreciably in the epidermis. However, the exact mechanism by which these bioactive agents can leave the epidermis are as yet unclear. This review addresses the potential role of microvesicle particles (MVP) as UVB signaling agents through transmitting biologic mediators. New data are provided that UVB treatment of human skin explants also generates MVP production. We hypothesize that UVB production of MVPs (UVB-MVP) could serve this important function of transmitting keratinocyte-derived bioactive agents. Moreover, we propose that UVB-MVP formation involves the lipid mediator platelet-activating factor. This novel pathway has the potential to be exploited pharmacologically to modulate UVB effects.

Original language	American English
Journal	Photochemistry and Photobiology
Volume	93
DOIs	https://doi.org/10.1111/php.12703
State	Published - Jul 1 2017

Disciplines

Chemicals and Drugs
Medical Toxicology
Medicine and Health Sciences

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10.1111/php.12703License: CC BY

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title = "UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects",

abstract = " Ultraviolet B radiation (UVB) exerts profound effects on human skin. Much is known regarding the ability of UVB to generate a plethora of bioactive agents ranging from cytokines and other bioactive proteins, lipid mediators and microRNAs. It is presumed that these agents are in large part responsible for the effects of UVB, which is only absorbed appreciably in the epidermis. However, the exact mechanism by which these bioactive agents can leave the epidermis are as yet unclear. This review addresses the potential role of microvesicle particles (MVP) as UVB signaling agents through transmitting biologic mediators. New data are provided that UVB treatment of human skin explants also generates MVP production. We hypothesize that UVB production of MVPs (UVB-MVP) could serve this important function of transmitting keratinocyte-derived bioactive agents. Moreover, we propose that UVB-MVP formation involves the lipid mediator platelet-activating factor. This novel pathway has the potential to be exploited pharmacologically to modulate UVB effects.",

author = "Fahy, {Katherine E.} and Langni Liu and Rapp, {Christine M.} and Borchers, {Christina E.} and Bihl, {Ji C.} and Yanfang Chen and Richard Simman and Travers, {Jeffrey B.}",

year = "2017",

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doi = "10.1111/php.12703",

language = "American English",

volume = "93",

journal = "Photochemistry and Photobiology",

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TY - JOUR

T1 - UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects

AU - Fahy, Katherine E.

AU - Liu, Langni

AU - Rapp, Christine M.

AU - Borchers, Christina E.

AU - Bihl, Ji C.

AU - Chen, Yanfang

AU - Simman, Richard

AU - Travers, Jeffrey B.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Ultraviolet B radiation (UVB) exerts profound effects on human skin. Much is known regarding the ability of UVB to generate a plethora of bioactive agents ranging from cytokines and other bioactive proteins, lipid mediators and microRNAs. It is presumed that these agents are in large part responsible for the effects of UVB, which is only absorbed appreciably in the epidermis. However, the exact mechanism by which these bioactive agents can leave the epidermis are as yet unclear. This review addresses the potential role of microvesicle particles (MVP) as UVB signaling agents through transmitting biologic mediators. New data are provided that UVB treatment of human skin explants also generates MVP production. We hypothesize that UVB production of MVPs (UVB-MVP) could serve this important function of transmitting keratinocyte-derived bioactive agents. Moreover, we propose that UVB-MVP formation involves the lipid mediator platelet-activating factor. This novel pathway has the potential to be exploited pharmacologically to modulate UVB effects.

AB - Ultraviolet B radiation (UVB) exerts profound effects on human skin. Much is known regarding the ability of UVB to generate a plethora of bioactive agents ranging from cytokines and other bioactive proteins, lipid mediators and microRNAs. It is presumed that these agents are in large part responsible for the effects of UVB, which is only absorbed appreciably in the epidermis. However, the exact mechanism by which these bioactive agents can leave the epidermis are as yet unclear. This review addresses the potential role of microvesicle particles (MVP) as UVB signaling agents through transmitting biologic mediators. New data are provided that UVB treatment of human skin explants also generates MVP production. We hypothesize that UVB production of MVPs (UVB-MVP) could serve this important function of transmitting keratinocyte-derived bioactive agents. Moreover, we propose that UVB-MVP formation involves the lipid mediator platelet-activating factor. This novel pathway has the potential to be exploited pharmacologically to modulate UVB effects.

UR - https://corescholar.libraries.wright.edu/ptox/149

U2 - 10.1111/php.12703

DO - 10.1111/php.12703

M3 - Article

C2 - 28039861

VL - 93

JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

ER -

UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects

Abstract

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