Volume Regulation of the Hippocampus

James E. Olson; Norman R. Kreisman

Volume Regulation of the Hippocampus

Wright State University

Research output: Other contribution

Abstract

We conclude that cellular taurine is critical for volume regulation of the hippocampus during swelling caused by oxidative stress. Both pyramidal neurons and astroglial cells accumulate taurine in slices treated to restore normal taurine contents. Since H2O2 exposure alters synaptic function via an oxidative mechanism in slices with normal or diminished slice taurine contents, we conclude the effects of taurine are not mediated by the antioxidant properties of the taurine molecule. We suggest loss of taurine from the slice exposed to oxidative stress facilitates regulation of normal cell volume via osmotic effects.

Original language	American English
State	Published - Jan 1 2005

Keywords

Hippocampus
astroglial cells
cellular taurine
oxidative stress
pyramidal neurons
volume regulation

Disciplines

Medical Cell Biology
Medical Neurobiology
Medical Physiology
Medical Sciences
Medicine and Health Sciences
Neurosciences
Physiological Processes

Cite this

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title = "Volume Regulation of the Hippocampus",

abstract = "We conclude that cellular taurine is critical for volume regulation of the hippocampus during swelling caused by oxidative stress. Both pyramidal neurons and astroglial cells accumulate taurine in slices treated to restore normal taurine contents. Since H2O2 exposure alters synaptic function via an oxidative mechanism in slices with normal or diminished slice taurine contents, we conclude the effects of taurine are not mediated by the antioxidant properties of the taurine molecule. We suggest loss of taurine from the slice exposed to oxidative stress facilitates regulation of normal cell volume via osmotic effects.",

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T1 - Volume Regulation of the Hippocampus

AU - Olson, James E.

AU - Kreisman, Norman R.

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N2 - We conclude that cellular taurine is critical for volume regulation of the hippocampus during swelling caused by oxidative stress. Both pyramidal neurons and astroglial cells accumulate taurine in slices treated to restore normal taurine contents. Since H2O2 exposure alters synaptic function via an oxidative mechanism in slices with normal or diminished slice taurine contents, we conclude the effects of taurine are not mediated by the antioxidant properties of the taurine molecule. We suggest loss of taurine from the slice exposed to oxidative stress facilitates regulation of normal cell volume via osmotic effects.

AB - We conclude that cellular taurine is critical for volume regulation of the hippocampus during swelling caused by oxidative stress. Both pyramidal neurons and astroglial cells accumulate taurine in slices treated to restore normal taurine contents. Since H2O2 exposure alters synaptic function via an oxidative mechanism in slices with normal or diminished slice taurine contents, we conclude the effects of taurine are not mediated by the antioxidant properties of the taurine molecule. We suggest loss of taurine from the slice exposed to oxidative stress facilitates regulation of normal cell volume via osmotic effects.

KW - Hippocampus

KW - astroglial cells

KW - cellular taurine

KW - oxidative stress

KW - pyramidal neurons

KW - volume regulation

UR - https://corescholar.libraries.wright.edu/ncbp/216

M3 - Other contribution

ER -

Volume Regulation of the Hippocampus

Abstract

Keywords

Disciplines

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Cite this