Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

Hari K. Somineni; Sini Nagpal; Suresh Venkateswaran; David J. Cutler; David T. Okou; Talin Haritunians; Claire L. Simpson; Ferdouse Begum; Lisa W. Datta; Antonio J. Quiros; Jenifer Seminerio; Emebet Mengesha; Jonathan S. Alexander; Robert N. Baldassano; Sharon Dudley-Brown; Raymond K. Cross; Themistocles Dassopoulos; Lee A. Denson; Tanvi A. Dhere; Heba Iskandar; Gerald W. Dryden; Jason K. Hou; Sunny Z. Hussain; Jeffrey S. Hyams; Kim L. Isaacs; Howard Kader; Michael D. Kappelman; Jeffry Katz; Richard Kellermayer; John F. Kuemmerle; Mark Lazarev; Ellen Li; Peter Mannon; Dedrick E. Moulton; Rodney D. Newberry; Ashish S. Patel; Joel Pekow; Shehzad A. Saeed; John F. Valentine; Ming Hsi Wang; Jacob L. McCauley; Maria T. Abreu; Traci Jester; Zarela Molle-Rios; Sirish Palle; Ellen J. Scherl; John Kwon; John D. Rioux; Richard H. Duerr; Mark S. Silverberg; Michael E. Zwick; Christine Stevens; Mark J. Daly; Judy H. Cho; Greg Gibson; Dermot P.B. McGovern; Steven R. Brant; Subra Kugathasan

doi:10.1016/j.ajhg.2021.02.001

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

Hari K. Somineni, Sini Nagpal, Suresh Venkateswaran, David J. Cutler, David T. Okou, Talin Haritunians, Claire L. Simpson, Ferdouse Begum, Lisa W. Datta, Antonio J. Quiros, Jenifer Seminerio, Emebet Mengesha, Jonathan S. Alexander, Robert N. Baldassano, Sharon Dudley-Brown, Raymond K. Cross, Themistocles Dassopoulos, Lee A. Denson, Tanvi A. Dhere, Heba IskandarGerald W. Dryden, Jason K. Hou, Sunny Z. Hussain, Jeffrey S. Hyams, Kim L. Isaacs, Howard Kader, Michael D. Kappelman, Jeffry Katz, Richard Kellermayer, John F. Kuemmerle, Mark Lazarev, Ellen Li, Peter Mannon, Dedrick E. Moulton, Rodney D. Newberry, Ashish S. Patel, Joel Pekow, Shehzad A. Saeed, John F. Valentine, Ming Hsi Wang, Jacob L. McCauley, Maria T. Abreu, Traci Jester, Zarela Molle-Rios, Sirish Palle, Ellen J. Scherl, John Kwon, John D. Rioux, Richard H. Duerr, Mark S. Silverberg, Michael E. Zwick, Christine Stevens, Mark J. Daly, Judy H. Cho, Greg Gibson, Dermot P.B. McGovern, Steven R. Brant, Subra Kugathasan

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	431-445
Number of pages	15
Journal	American Journal of Human Genetics
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2021.02.001
State	Published - Mar 4 2021
Externally published	Yes

ASJC Scopus Subject Areas

Genetics
Genetics(clinical)

Keywords

CALB2
PTGER4
differential genetic architecture
polygenic risk scores
rare variants
trans-ethnic comparative analysis
understudied populations
whole-genome sequencing of African Americans

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10.1016/j.ajhg.2021.02.001

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Somineni, H. K., Nagpal, S., Venkateswaran, S., Cutler, D. J., Okou, D. T., Haritunians, T., Simpson, C. L., Begum, F., Datta, L. W., Quiros, A. J., Seminerio, J., Mengesha, E., Alexander, J. S., Baldassano, R. N., Dudley-Brown, S., Cross, R. K., Dassopoulos, T., Denson, L. A., Dhere, T. A., ... Kugathasan, S. (2021). Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. American Journal of Human Genetics, 108(3), 431-445. https://doi.org/10.1016/j.ajhg.2021.02.001

Somineni, HK, Nagpal, S, Venkateswaran, S, Cutler, DJ, Okou, DT, Haritunians, T, Simpson, CL, Begum, F, Datta, LW, Quiros, AJ, Seminerio, J, Mengesha, E, Alexander, JS, Baldassano, RN, Dudley-Brown, S, Cross, RK, Dassopoulos, T, Denson, LA, Dhere, TA, Iskandar, H, Dryden, GW, Hou, JK, Hussain, SZ, Hyams, JS, Isaacs, KL, Kader, H, Kappelman, MD, Katz, J, Kellermayer, R, Kuemmerle, JF, Lazarev, M, Li, E, Mannon, P, Moulton, DE, Newberry, RD, Patel, AS, Pekow, J, Saeed, SA, Valentine, JF, Wang, MH, McCauley, JL, Abreu, MT, Jester, T, Molle-Rios, Z, Palle, S, Scherl, EJ, Kwon, J, Rioux, JD, Duerr, RH, Silverberg, MS, Zwick, ME, Stevens, C, Daly, MJ, Cho, JH, Gibson, G, McGovern, DPB, Brant, SR & Kugathasan, S 2021, 'Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease', American Journal of Human Genetics, vol. 108, no. 3, pp. 431-445. https://doi.org/10.1016/j.ajhg.2021.02.001

@article{0db6c70757d2435e9856c13033a334f2,

title = "Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease",

keywords = "CALB2, PTGER4, differential genetic architecture, polygenic risk scores, rare variants, trans-ethnic comparative analysis, understudied populations, whole-genome sequencing of African Americans",

author = "Somineni, \{Hari K.\} and Sini Nagpal and Suresh Venkateswaran and Cutler, \{David J.\} and Okou, \{David T.\} and Talin Haritunians and Simpson, \{Claire L.\} and Ferdouse Begum and Datta, \{Lisa W.\} and Quiros, \{Antonio J.\} and Jenifer Seminerio and Emebet Mengesha and Alexander, \{Jonathan S.\} and Baldassano, \{Robert N.\} and Sharon Dudley-Brown and Cross, \{Raymond K.\} and Themistocles Dassopoulos and Denson, \{Lee A.\} and Dhere, \{Tanvi A.\} and Heba Iskandar and Dryden, \{Gerald W.\} and Hou, \{Jason K.\} and Hussain, \{Sunny Z.\} and Hyams, \{Jeffrey S.\} and Isaacs, \{Kim L.\} and Howard Kader and Kappelman, \{Michael D.\} and Jeffry Katz and Richard Kellermayer and Kuemmerle, \{John F.\} and Mark Lazarev and Ellen Li and Peter Mannon and Moulton, \{Dedrick E.\} and Newberry, \{Rodney D.\} and Patel, \{Ashish S.\} and Joel Pekow and Saeed, \{Shehzad A.\} and Valentine, \{John F.\} and Wang, \{Ming Hsi\} and McCauley, \{Jacob L.\} and Abreu, \{Maria T.\} and Traci Jester and Zarela Molle-Rios and Sirish Palle and Scherl, \{Ellen J.\} and John Kwon and Rioux, \{John D.\} and Duerr, \{Richard H.\} and Silverberg, \{Mark S.\} and Zwick, \{Michael E.\} and Christine Stevens and Daly, \{Mark J.\} and Cho, \{Judy H.\} and Greg Gibson and McGovern, \{Dermot P.B.\} and Brant, \{Steven R.\} and Subra Kugathasan",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = mar,

day = "4",

doi = "10.1016/j.ajhg.2021.02.001",

language = "English",

volume = "108",

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journal = "American Journal of Human Genetics",

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AU - Somineni, Hari K.

AU - Nagpal, Sini

AU - Venkateswaran, Suresh

AU - Cutler, David J.

AU - Okou, David T.

AU - Haritunians, Talin

AU - Simpson, Claire L.

AU - Begum, Ferdouse

AU - Datta, Lisa W.

AU - Quiros, Antonio J.

AU - Seminerio, Jenifer

AU - Mengesha, Emebet

AU - Alexander, Jonathan S.

AU - Baldassano, Robert N.

AU - Dudley-Brown, Sharon

AU - Cross, Raymond K.

AU - Dassopoulos, Themistocles

AU - Denson, Lee A.

AU - Dhere, Tanvi A.

AU - Iskandar, Heba

AU - Dryden, Gerald W.

AU - Hou, Jason K.

AU - Hussain, Sunny Z.

AU - Hyams, Jeffrey S.

AU - Isaacs, Kim L.

AU - Kader, Howard

AU - Kappelman, Michael D.

AU - Katz, Jeffry

AU - Kellermayer, Richard

AU - Kuemmerle, John F.

AU - Lazarev, Mark

AU - Li, Ellen

AU - Mannon, Peter

AU - Moulton, Dedrick E.

AU - Newberry, Rodney D.

AU - Patel, Ashish S.

AU - Pekow, Joel

AU - Saeed, Shehzad A.

AU - Valentine, John F.

AU - Wang, Ming Hsi

AU - McCauley, Jacob L.

AU - Abreu, Maria T.

AU - Jester, Traci

AU - Molle-Rios, Zarela

AU - Palle, Sirish

AU - Scherl, Ellen J.

AU - Kwon, John

AU - Rioux, John D.

AU - Duerr, Richard H.

AU - Silverberg, Mark S.

AU - Zwick, Michael E.

AU - Stevens, Christine

AU - Daly, Mark J.

AU - Cho, Judy H.

AU - Gibson, Greg

AU - McGovern, Dermot P.B.

AU - Brant, Steven R.

AU - Kugathasan, Subra

PY - 2021/3/4

Y1 - 2021/3/4

KW - CALB2

KW - PTGER4

KW - differential genetic architecture

KW - polygenic risk scores

KW - rare variants

KW - trans-ethnic comparative analysis

KW - understudied populations

KW - whole-genome sequencing of African Americans

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C2 - 33600772

AN - SCOPUS:85101760548

SN - 0002-9297

VL - 108

SP - 431

EP - 445

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

ASJC Scopus Subject Areas

Keywords

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